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Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter.

Publication ,  Journal Article
Taylor, WD; MacFall, JR; Payne, ME; McQuoid, DR; Provenzale, JM; Steffens, DC; Krishnan, KRR
Published in: Am J Psychiatry
July 2004

OBJECTIVE: The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression. METHOD: Seventeen elderly depressed subjects were compared with 16 elderly subjects who were not depressed. Diffusion tensor imaging was used to measure the fractional anisotropy of the white matter in the dorsolateral prefrontal cortex's superior and middle frontal gyri bilaterally and in the left occipital lobe as a control region. The authors compared results between groups while controlling for age, sex, and comorbid medical disorders. RESULTS: Even after controlling for age, sex, hypertension, and heart disease, the authors found significantly lower fractional anisotropy values in the right superior frontal gyrus white matter of depressed patients than comparison subjects. CONCLUSIONS: Microstructural changes in the white matter of the right superior frontal gyrus are associated with late-life depression. Further work is needed to determine how these changes contribute to depression outcomes.

Duke Scholars

Published In

Am J Psychiatry

DOI

ISSN

0002-953X

Publication Date

July 2004

Volume

161

Issue

7

Start / End Page

1293 / 1296

Location

United States

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Prefrontal Cortex
  • Occipital Lobe
  • Neural Pathways
  • Middle Aged
  • Male
  • Image Processing, Computer-Assisted
  • Hypertension
  • Humans
 

Citation

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ICMJE
MLA
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Taylor, W. D., MacFall, J. R., Payne, M. E., McQuoid, D. R., Provenzale, J. M., Steffens, D. C., & Krishnan, K. R. R. (2004). Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter. Am J Psychiatry, 161(7), 1293–1296. https://doi.org/10.1176/appi.ajp.161.7.1293
Taylor, Warren D., James R. MacFall, Martha E. Payne, Douglas R. McQuoid, James M. Provenzale, David C. Steffens, and K Ranga Rama Krishnan. “Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter.Am J Psychiatry 161, no. 7 (July 2004): 1293–96. https://doi.org/10.1176/appi.ajp.161.7.1293.
Taylor WD, MacFall JR, Payne ME, McQuoid DR, Provenzale JM, Steffens DC, et al. Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter. Am J Psychiatry. 2004 Jul;161(7):1293–6.
Taylor, Warren D., et al. “Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter.Am J Psychiatry, vol. 161, no. 7, July 2004, pp. 1293–96. Pubmed, doi:10.1176/appi.ajp.161.7.1293.
Taylor WD, MacFall JR, Payne ME, McQuoid DR, Provenzale JM, Steffens DC, Krishnan KRR. Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter. Am J Psychiatry. 2004 Jul;161(7):1293–1296.
Journal cover image

Published In

Am J Psychiatry

DOI

ISSN

0002-953X

Publication Date

July 2004

Volume

161

Issue

7

Start / End Page

1293 / 1296

Location

United States

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Prefrontal Cortex
  • Occipital Lobe
  • Neural Pathways
  • Middle Aged
  • Male
  • Image Processing, Computer-Assisted
  • Hypertension
  • Humans