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Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony.

Publication ,  Journal Article
Trimble, MA; Velazquez, EJ; Adams, GL; Honeycutt, EF; Pagnanelli, RA; Barnhart, HX; Chen, J; Iskandrian, AE; Garcia, EV; Borges-Neto, S
Published in: Nucl Med Commun
April 2008

BACKGROUND: A novel method to quantify dyssynchrony has been developed using phase analysis of gated single-photon emission computed tomography perfusion imaging. We report on the effect of variability in image reconstruction on the phase analysis results (repeatability) and on the interobserver and intraobserver reproducibility of the technique. METHODS: Phase standard deviation (SD) and bandwidth are phase indices that quantify dyssynchrony. To evaluate repeatability, raw data sets were processed twice in 50 patients with left ventricular dysfunction and 50 normal controls. To determine the optimal processing method, two replicated phase analysis results were obtained using automated and manual base parameter placement. Reproducibility of the phase analysis was determined using the data from 20 patients. RESULTS: In normal controls, manual base parameter placement improves repeatability of the phase analysis as measured by the mean absolute difference between two reads for phase SD (12.0 degrees vs. 1.2 degrees , P<0.0001) and bandwidth (33.7 degrees vs. 3.6 degrees , P<0.0001). Repeatability is better for normal controls than for patients with left ventricular dysfunction for phase SD (1.2 degrees vs. 6.0 degrees , P<0.0001) and bandwidth (3.6 degrees vs. 26.5 degrees , P<0.0001). Reproducibility of the phase analysis is high as measured by the intraclass correlation coefficients for phase SD and bandwidth of 0.99 and 0.99 for the interobserver comparisons and 1.00 and 1.00 for the intraobserver comparisons. CONCLUSION: A novel method to quantify dyssynchrony has been developed using gated single-photon emission computed tomography perfusion imaging. Manual base parameter placement reduces the effect that variability in image reconstruction has on phase analysis. A high degree of reproducibility of phase analysis is observed.

Duke Scholars

Published In

Nucl Med Commun

DOI

ISSN

0143-3636

Publication Date

April 2008

Volume

29

Issue

4

Start / End Page

374 / 381

Location

England

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Tomography, Emission-Computed, Single-Photon
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Perfusion
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Trimble, M. A., Velazquez, E. J., Adams, G. L., Honeycutt, E. F., Pagnanelli, R. A., Barnhart, H. X., … Borges-Neto, S. (2008). Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony. Nucl Med Commun, 29(4), 374–381. https://doi.org/10.1097/MNM.0b013e3282f81380
Trimble, Mark A., Eric J. Velazquez, George L. Adams, Emily F. Honeycutt, Robert A. Pagnanelli, Huiman X. Barnhart, Ji Chen, Ami E. Iskandrian, Ernest V. Garcia, and Salvador Borges-Neto. “Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony.Nucl Med Commun 29, no. 4 (April 2008): 374–81. https://doi.org/10.1097/MNM.0b013e3282f81380.
Trimble MA, Velazquez EJ, Adams GL, Honeycutt EF, Pagnanelli RA, Barnhart HX, et al. Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony. Nucl Med Commun. 2008 Apr;29(4):374–81.
Trimble, Mark A., et al. “Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony.Nucl Med Commun, vol. 29, no. 4, Apr. 2008, pp. 374–81. Pubmed, doi:10.1097/MNM.0b013e3282f81380.
Trimble MA, Velazquez EJ, Adams GL, Honeycutt EF, Pagnanelli RA, Barnhart HX, Chen J, Iskandrian AE, Garcia EV, Borges-Neto S. Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony. Nucl Med Commun. 2008 Apr;29(4):374–381.

Published In

Nucl Med Commun

DOI

ISSN

0143-3636

Publication Date

April 2008

Volume

29

Issue

4

Start / End Page

374 / 381

Location

England

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Tomography, Emission-Computed, Single-Photon
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Perfusion
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Image Interpretation, Computer-Assisted
  • Image Enhancement