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Electromagnetic spectroscopy of normal breast tissue specimens obtained from reduction surgeries: comparison of optical and microwave properties.

Publication ,  Journal Article
Lazebnik, M; Zhu, C; Palmer, GM; Harter, J; Sewall, S; Ramanujam, N; Hagness, SC
Published in: IEEE Trans Biomed Eng
October 2008

Techniques utilizing electromagnetic energy at microwave and optical frequencies have been shown to be promising for breast cancer detection and diagnosis. Since different biophysical mechanisms are exploited at these frequencies to discriminate between healthy and diseased tissue, combining these two modalities may result in a more powerful approach for breast cancer detection and diagnosis. Toward this end, we performed microwave dielectric spectroscopy and optical diffuse reflectance spectroscopy measurements at the same sites on freshly excised normal breast tissues obtained from reduction surgeries at the University of Wisconsin Hospital, using microwave and optical probes with very similar sensing volumes. We found that the microwave dielectric constant and effective conductivity are correlated with tissue composition across the entire measurement frequency range (|r| approximately 0.5-0.6, p<0.01) and that the optical absorption coefficient at 460 nm and optical scattering coefficient are correlated with tissue composition (|r| approximately 0.4-0.6, p<0.02). Finally, we found that the optical absorption coefficient at 460 nm is correlated with the microwave dielectric constant and effective conductivity (r=-0.55, p<0.01). Our results suggest that combining optical and microwave modalities for analyzing breast tissue samples may serve as a crosscheck and provide complementary information about tissue composition.

Duke Scholars

Published In

IEEE Trans Biomed Eng

DOI

EISSN

1558-2531

Publication Date

October 2008

Volume

55

Issue

10

Start / End Page

2444 / 2451

Location

United States

Related Subject Headings

  • Spectrum Analysis
  • Spectrophotometry
  • Scattering, Radiation
  • Middle Aged
  • Microwaves
  • Mammaplasty
  • Light
  • Humans
  • Female
  • Electromagnetic Phenomena
 

Citation

APA
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ICMJE
MLA
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Lazebnik, M., Zhu, C., Palmer, G. M., Harter, J., Sewall, S., Ramanujam, N., & Hagness, S. C. (2008). Electromagnetic spectroscopy of normal breast tissue specimens obtained from reduction surgeries: comparison of optical and microwave properties. IEEE Trans Biomed Eng, 55(10), 2444–2451. https://doi.org/10.1109/TBME.2008.925700
Lazebnik, Mariya, Changfang Zhu, Gregory M. Palmer, Josephine Harter, Sarah Sewall, Nirmala Ramanujam, and Susan C. Hagness. “Electromagnetic spectroscopy of normal breast tissue specimens obtained from reduction surgeries: comparison of optical and microwave properties.IEEE Trans Biomed Eng 55, no. 10 (October 2008): 2444–51. https://doi.org/10.1109/TBME.2008.925700.
Lazebnik M, Zhu C, Palmer GM, Harter J, Sewall S, Ramanujam N, et al. Electromagnetic spectroscopy of normal breast tissue specimens obtained from reduction surgeries: comparison of optical and microwave properties. IEEE Trans Biomed Eng. 2008 Oct;55(10):2444–51.
Lazebnik, Mariya, et al. “Electromagnetic spectroscopy of normal breast tissue specimens obtained from reduction surgeries: comparison of optical and microwave properties.IEEE Trans Biomed Eng, vol. 55, no. 10, Oct. 2008, pp. 2444–51. Pubmed, doi:10.1109/TBME.2008.925700.
Lazebnik M, Zhu C, Palmer GM, Harter J, Sewall S, Ramanujam N, Hagness SC. Electromagnetic spectroscopy of normal breast tissue specimens obtained from reduction surgeries: comparison of optical and microwave properties. IEEE Trans Biomed Eng. 2008 Oct;55(10):2444–2451.

Published In

IEEE Trans Biomed Eng

DOI

EISSN

1558-2531

Publication Date

October 2008

Volume

55

Issue

10

Start / End Page

2444 / 2451

Location

United States

Related Subject Headings

  • Spectrum Analysis
  • Spectrophotometry
  • Scattering, Radiation
  • Middle Aged
  • Microwaves
  • Mammaplasty
  • Light
  • Humans
  • Female
  • Electromagnetic Phenomena