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Monte-Carlo-based model for the extraction of intrinsic fluorescence from turbid media.

Publication ,  Journal Article
Palmer, GM; Ramanujam, N
Published in: J Biomed Opt
2008

A Monte-Carlo-based model of fluorescence is developed that is capable of extracting the intrinsic fluorescence properties of tissue, which are independent of the absorption and scattering properties of tissue. This model is flexible in its applicability to different illumination-collection geometries and is also valid for a wide range of optical properties, representative of tissue in the UV-visible spectrum. This is potentially useful in a variety of biomedical applications, including cancer diagnostics and monitoring the physiological response to therapy. The model is validated using phantoms composed of hemoglobin (absorber), polystyrene spheres (scatterer), and furan-2 (fluorophore). It is found that this model is able to retrieve the intrinsic fluorescence spectra of the tissue phantoms and recover the intrinsic fluorescence intensity of furan within the phantoms to within a mean error of less than 10%.

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Published In

J Biomed Opt

DOI

ISSN

1083-3668

Publication Date

2008

Volume

13

Issue

2

Start / End Page

024017

Location

United States

Related Subject Headings

  • Spectrometry, Fluorescence
  • Optics
  • Nephelometry and Turbidimetry
  • Monte Carlo Method
  • Models, Statistical
  • Models, Chemical
  • Models, Biological
  • Computer Simulation
  • Colloids
  • 5102 Atomic, molecular and optical physics
 

Citation

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Palmer, G. M., & Ramanujam, N. (2008). Monte-Carlo-based model for the extraction of intrinsic fluorescence from turbid media. J Biomed Opt, 13(2), 024017. https://doi.org/10.1117/1.2907161
Palmer, Gregory M., and Nirmala Ramanujam. “Monte-Carlo-based model for the extraction of intrinsic fluorescence from turbid media.J Biomed Opt 13, no. 2 (2008): 024017. https://doi.org/10.1117/1.2907161.
Palmer, Gregory M., and Nirmala Ramanujam. “Monte-Carlo-based model for the extraction of intrinsic fluorescence from turbid media.J Biomed Opt, vol. 13, no. 2, 2008, p. 024017. Pubmed, doi:10.1117/1.2907161.

Published In

J Biomed Opt

DOI

ISSN

1083-3668

Publication Date

2008

Volume

13

Issue

2

Start / End Page

024017

Location

United States

Related Subject Headings

  • Spectrometry, Fluorescence
  • Optics
  • Nephelometry and Turbidimetry
  • Monte Carlo Method
  • Models, Statistical
  • Models, Chemical
  • Models, Biological
  • Computer Simulation
  • Colloids
  • 5102 Atomic, molecular and optical physics