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Histopathological variation in keratoconus.

Publication ,  Journal Article
Scroggs, MW; Proia, AD
Published in: Cornea
November 1992

During examination of 131 penetrating keratoplasty specimens from patients with keratoconus obtained in an 11-year period, we observed two histopathologic variants based on the appearance of Bowman's layer and the corneal epithelium. "Typical" keratoconus specimens had multiple breaks in Bowman's layer and central epithelial thinning, whereas "atypical" corneas lacked breaks in Bowman's layer and had less thinning of the central epithelium. Ninety-five corneas were from patients who underwent grafting in only one eye. Seventy-six (80%) of these corneas were "typical" and 19 corneas (20%) were "atypical" in appearance. Both variants had similar degrees of central stromal thinning. Patients with "typical" and "atypical" corneas differed demographically by race only; 49% of "typical" and 95% of "atypical" corneas were from white individuals. Thirty-six corneas were from 18 patients who underwent bilateral penetrating keratoplasty. The histologic appearance of these corneal pairs was concordant in 13 patients and discordant (one "typical" and one "atypical" cornea) in five patients. Statistical analysis indicated that this distribution is not significantly different from that predicted by chance and suggests that "typical" and "atypical" corneas are manifestations of the same disease process.

Duke Scholars

Published In

Cornea

DOI

ISSN

0277-3740

Publication Date

November 1992

Volume

11

Issue

6

Start / End Page

553 / 559

Location

United States

Related Subject Headings

  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Keratoplasty, Penetrating
  • Keratoconus
  • Humans
  • Female
  • Epithelium
  • Corneal Stroma
  • Cornea
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Scroggs, M. W., & Proia, A. D. (1992). Histopathological variation in keratoconus. Cornea, 11(6), 553–559. https://doi.org/10.1097/00003226-199211000-00012
Scroggs, M. W., and A. D. Proia. “Histopathological variation in keratoconus.Cornea 11, no. 6 (November 1992): 553–59. https://doi.org/10.1097/00003226-199211000-00012.
Scroggs MW, Proia AD. Histopathological variation in keratoconus. Cornea. 1992 Nov;11(6):553–9.
Scroggs, M. W., and A. D. Proia. “Histopathological variation in keratoconus.Cornea, vol. 11, no. 6, Nov. 1992, pp. 553–59. Pubmed, doi:10.1097/00003226-199211000-00012.
Scroggs MW, Proia AD. Histopathological variation in keratoconus. Cornea. 1992 Nov;11(6):553–559.

Published In

Cornea

DOI

ISSN

0277-3740

Publication Date

November 1992

Volume

11

Issue

6

Start / End Page

553 / 559

Location

United States

Related Subject Headings

  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Keratoplasty, Penetrating
  • Keratoconus
  • Humans
  • Female
  • Epithelium
  • Corneal Stroma
  • Cornea