Skip to main content
Journal cover image

Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment.

Publication ,  Journal Article
Chandler, DB; Hida, T; Sheta, S; Proia, AD; Machemer, R
Published in: Graefes Arch Clin Exp Ophthalmol
1987

Intraocular injection of the corticosteroid triamcinolone acetonide reduces the incidence of retinal detachment in rabbit eyes injected with tissue-cultured fibroblasts. When the steroid was injected simultaneously with the cells, a reduction of retinal detachment from 93% (control) to 75% (treated) was achieved on day 28. When the steroid was injected 24 h preceding cell injection, the reduction of retinal detachment was from 85% (control) to 43% (treated). The development of retinal detachment is caused by proliferation of injected fibroblasts. Reduction of this proliferation is probably achieved partially through direct inhibition of mitosis, but more important may be the reduction of the reactive inflammatory process.

Duke Scholars

Published In

Graefes Arch Clin Exp Ophthalmol

DOI

ISSN

0721-832X

Publication Date

1987

Volume

225

Issue

4

Start / End Page

259 / 265

Location

Germany

Related Subject Headings

  • Vitreous Body
  • Triamcinolone Acetonide
  • Transplantation, Homologous
  • Retinal Diseases
  • Retinal Detachment
  • Rabbits
  • Ophthalmology & Optometry
  • Fibroblasts
  • Eye Diseases
  • Drug Evaluation, Preclinical
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chandler, D. B., Hida, T., Sheta, S., Proia, A. D., & Machemer, R. (1987). Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment. Graefes Arch Clin Exp Ophthalmol, 225(4), 259–265. https://doi.org/10.1007/BF02150144
Chandler, D. B., T. Hida, S. Sheta, A. D. Proia, and R. Machemer. “Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment.Graefes Arch Clin Exp Ophthalmol 225, no. 4 (1987): 259–65. https://doi.org/10.1007/BF02150144.
Chandler DB, Hida T, Sheta S, Proia AD, Machemer R. Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment. Graefes Arch Clin Exp Ophthalmol. 1987;225(4):259–65.
Chandler, D. B., et al. “Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment.Graefes Arch Clin Exp Ophthalmol, vol. 225, no. 4, 1987, pp. 259–65. Pubmed, doi:10.1007/BF02150144.
Chandler DB, Hida T, Sheta S, Proia AD, Machemer R. Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment. Graefes Arch Clin Exp Ophthalmol. 1987;225(4):259–265.
Journal cover image

Published In

Graefes Arch Clin Exp Ophthalmol

DOI

ISSN

0721-832X

Publication Date

1987

Volume

225

Issue

4

Start / End Page

259 / 265

Location

Germany

Related Subject Headings

  • Vitreous Body
  • Triamcinolone Acetonide
  • Transplantation, Homologous
  • Retinal Diseases
  • Retinal Detachment
  • Rabbits
  • Ophthalmology & Optometry
  • Fibroblasts
  • Eye Diseases
  • Drug Evaluation, Preclinical