Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment.
Publication
, Journal Article
Chandler, DB; Hida, T; Sheta, S; Proia, AD; Machemer, R
Published in: Graefes Arch Clin Exp Ophthalmol
1987
Intraocular injection of the corticosteroid triamcinolone acetonide reduces the incidence of retinal detachment in rabbit eyes injected with tissue-cultured fibroblasts. When the steroid was injected simultaneously with the cells, a reduction of retinal detachment from 93% (control) to 75% (treated) was achieved on day 28. When the steroid was injected 24 h preceding cell injection, the reduction of retinal detachment was from 85% (control) to 43% (treated). The development of retinal detachment is caused by proliferation of injected fibroblasts. Reduction of this proliferation is probably achieved partially through direct inhibition of mitosis, but more important may be the reduction of the reactive inflammatory process.
Duke Scholars
Published In
Graefes Arch Clin Exp Ophthalmol
DOI
ISSN
0721-832X
Publication Date
1987
Volume
225
Issue
4
Start / End Page
259 / 265
Location
Germany
Related Subject Headings
- Vitreous Body
- Triamcinolone Acetonide
- Transplantation, Homologous
- Retinal Diseases
- Retinal Detachment
- Rabbits
- Ophthalmology & Optometry
- Fibroblasts
- Eye Diseases
- Drug Evaluation, Preclinical
Citation
APA
Chicago
ICMJE
MLA
NLM
Chandler, D. B., Hida, T., Sheta, S., Proia, A. D., & Machemer, R. (1987). Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment. Graefes Arch Clin Exp Ophthalmol, 225(4), 259–265. https://doi.org/10.1007/BF02150144
Chandler, D. B., T. Hida, S. Sheta, A. D. Proia, and R. Machemer. “Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment.” Graefes Arch Clin Exp Ophthalmol 225, no. 4 (1987): 259–65. https://doi.org/10.1007/BF02150144.
Chandler DB, Hida T, Sheta S, Proia AD, Machemer R. Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment. Graefes Arch Clin Exp Ophthalmol. 1987;225(4):259–65.
Chandler, D. B., et al. “Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment.” Graefes Arch Clin Exp Ophthalmol, vol. 225, no. 4, 1987, pp. 259–65. Pubmed, doi:10.1007/BF02150144.
Chandler DB, Hida T, Sheta S, Proia AD, Machemer R. Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment. Graefes Arch Clin Exp Ophthalmol. 1987;225(4):259–265.
Published In
Graefes Arch Clin Exp Ophthalmol
DOI
ISSN
0721-832X
Publication Date
1987
Volume
225
Issue
4
Start / End Page
259 / 265
Location
Germany
Related Subject Headings
- Vitreous Body
- Triamcinolone Acetonide
- Transplantation, Homologous
- Retinal Diseases
- Retinal Detachment
- Rabbits
- Ophthalmology & Optometry
- Fibroblasts
- Eye Diseases
- Drug Evaluation, Preclinical