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Cytomegalovirus keratitis after penetrating keratoplasty.

Publication ,  Journal Article
Wehrly, SR; Manning, FJ; Proia, AD; Burchette, JL; Foulks, GN
Published in: Cornea
November 1995

We report the development of cytomegalovirus (CMV) keratitis in the penetrating keratoplasty of a 59-year-old human immunodeficiency virus-negative woman after uncomplicated corneal transplantation. Immunosuppression with topical cyclosporine A 2% in corn oil and topical prednisolone acetate 1% suspension was used postoperatively. The 15-month postoperative course was complicated by multiple episodes of endothelial rejection, medically controlled elevated intraocular pressure, polymicrobial bacterial (coagulase-negative staphlococcus and alpha-hemolytic streptococcus) keratitis, and endothelial plaque formation with associated hypopyon and epithelial defect. The graft failed and penetrating keratoplasty was repeated. Cytomegalovirus infection of superficial keratocytes in a region of scarring was identified in histological sections stained with hematoxylin and eosin and confirmed using mouse monoclonal anti-cytomegalovirus antibodies. Excision of the diseased corneal button with no additional treatment appears to have been curative. Low-grade keratitis was the only manifestation of the CMV infection, and it has not recurred 6 months postoperatively.

Duke Scholars

Published In

Cornea

ISSN

0277-3740

Publication Date

November 1995

Volume

14

Issue

6

Start / End Page

628 / 633

Location

United States

Related Subject Headings

  • Reoperation
  • Prednisolone
  • Ophthalmology & Optometry
  • Ophthalmic Solutions
  • Middle Aged
  • Keratoplasty, Penetrating
  • Keratitis
  • Immunosuppressive Agents
  • Immunoenzyme Techniques
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wehrly, S. R., Manning, F. J., Proia, A. D., Burchette, J. L., & Foulks, G. N. (1995). Cytomegalovirus keratitis after penetrating keratoplasty. Cornea, 14(6), 628–633.
Wehrly, S. R., F. J. Manning, A. D. Proia, J. L. Burchette, and G. N. Foulks. “Cytomegalovirus keratitis after penetrating keratoplasty.Cornea 14, no. 6 (November 1995): 628–33.
Wehrly SR, Manning FJ, Proia AD, Burchette JL, Foulks GN. Cytomegalovirus keratitis after penetrating keratoplasty. Cornea. 1995 Nov;14(6):628–33.
Wehrly, S. R., et al. “Cytomegalovirus keratitis after penetrating keratoplasty.Cornea, vol. 14, no. 6, Nov. 1995, pp. 628–33.
Wehrly SR, Manning FJ, Proia AD, Burchette JL, Foulks GN. Cytomegalovirus keratitis after penetrating keratoplasty. Cornea. 1995 Nov;14(6):628–633.

Published In

Cornea

ISSN

0277-3740

Publication Date

November 1995

Volume

14

Issue

6

Start / End Page

628 / 633

Location

United States

Related Subject Headings

  • Reoperation
  • Prednisolone
  • Ophthalmology & Optometry
  • Ophthalmic Solutions
  • Middle Aged
  • Keratoplasty, Penetrating
  • Keratitis
  • Immunosuppressive Agents
  • Immunoenzyme Techniques
  • Humans