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A new paradigm for corneal wound healing research: the white leghorn chicken (Gallus gallus domesticus).

Publication ,  Journal Article
Fowler, WC; Chang, DH; Roberts, BC; Zarovnaya, EL; Proia, AD
Published in: Curr Eye Res
April 2004

PURPOSE: To evaluate the chicken cornea as a model for corneal wound healing research. METHODS: We conducted studies on normal chicken corneas and on corneas following mechanical debridement and photorefractive keratectomy (PRK). RESULTS: The chicken cornea possesses six distinct layers that resemble the layers of the human cornea, including a substantial Bowman's layer measuring 5.2 +/- 0.3 microm thick. Reepithelialization time was 44.8 +/- 1.1 hours with a sliding rate of 75.3 +/- 3.2 microm/hour following mechanical debridement and 54.4 +/- 2.8 hours with a sliding rate of 63.3 +/- 3.2 microm/hour for PRK-treated corneas. Biomicroscopic haze post-PRK peaked at 4-6 weeks and regressed until 20 weeks post-PRK. Histologic and clinical observations of wound healing strongly paralleled that noted in humans. CONCLUSION: The chicken cornea's morphology and wound healing response render it a useful model for corneal wound healing investigations.

Duke Scholars

Published In

Curr Eye Res

DOI

ISSN

0271-3683

Publication Date

April 2004

Volume

28

Issue

4

Start / End Page

241 / 250

Location

England

Related Subject Headings

  • Wound Healing
  • Photorefractive Keratectomy
  • Ophthalmology & Optometry
  • Lasers, Excimer
  • Fibroblasts
  • Female
  • Epithelium, Corneal
  • Endothelium, Corneal
  • Disease Models, Animal
  • Debridement
 

Citation

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MLA
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Fowler, W. C., Chang, D. H., Roberts, B. C., Zarovnaya, E. L., & Proia, A. D. (2004). A new paradigm for corneal wound healing research: the white leghorn chicken (Gallus gallus domesticus). Curr Eye Res, 28(4), 241–250. https://doi.org/10.1076/ceyr.28.4.241.27837
Fowler, W Craig, Daniel H. Chang, Bruce Clyde Roberts, Elena L. Zarovnaya, and Alan D. Proia. “A new paradigm for corneal wound healing research: the white leghorn chicken (Gallus gallus domesticus).Curr Eye Res 28, no. 4 (April 2004): 241–50. https://doi.org/10.1076/ceyr.28.4.241.27837.
Fowler WC, Chang DH, Roberts BC, Zarovnaya EL, Proia AD. A new paradigm for corneal wound healing research: the white leghorn chicken (Gallus gallus domesticus). Curr Eye Res. 2004 Apr;28(4):241–50.
Fowler, W. Craig, et al. “A new paradigm for corneal wound healing research: the white leghorn chicken (Gallus gallus domesticus).Curr Eye Res, vol. 28, no. 4, Apr. 2004, pp. 241–50. Pubmed, doi:10.1076/ceyr.28.4.241.27837.
Fowler WC, Chang DH, Roberts BC, Zarovnaya EL, Proia AD. A new paradigm for corneal wound healing research: the white leghorn chicken (Gallus gallus domesticus). Curr Eye Res. 2004 Apr;28(4):241–250.
Journal cover image

Published In

Curr Eye Res

DOI

ISSN

0271-3683

Publication Date

April 2004

Volume

28

Issue

4

Start / End Page

241 / 250

Location

England

Related Subject Headings

  • Wound Healing
  • Photorefractive Keratectomy
  • Ophthalmology & Optometry
  • Lasers, Excimer
  • Fibroblasts
  • Female
  • Epithelium, Corneal
  • Endothelium, Corneal
  • Disease Models, Animal
  • Debridement