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A new cardiac MASTer switch for the renin-angiotensin system.

Publication ,  Journal Article
Le, TH; Coffman, TM
Published in: J Clin Invest
April 2006

The aspartyl protease renin was first isolated from the kidney by Tigerstedt more than a century ago. In the kidney, renin secretion is tightly linked to sodium intake and renal perfusion pressure, reflecting the important role of the renin-angiotensin system (RAS) in controlling body fluid volume and blood pressure. The study by Mackins et al. in this issue of the JCI describes a novel source of renin: the mast cell (see the related article beginning on page 1063). This discovery suggests a distinct pathway for activation of the RAS that may have a particular impact on the pathogenesis of chronic tissue injury as well as more acute pathology such as arrhythmias in the heart.

Duke Scholars

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

April 2006

Volume

116

Issue

4

Start / End Page

866 / 869

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Renin
  • Myocardium
  • Mast Cells
  • Immunology
  • Humans
  • Cardiovascular Diseases
  • Blood Pressure
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Le, T. H., & Coffman, T. M. (2006). A new cardiac MASTer switch for the renin-angiotensin system. J Clin Invest, 116(4), 866–869. https://doi.org/10.1172/JCI28312
Le, Thu H., and Thomas M. Coffman. “A new cardiac MASTer switch for the renin-angiotensin system.J Clin Invest 116, no. 4 (April 2006): 866–69. https://doi.org/10.1172/JCI28312.
Le TH, Coffman TM. A new cardiac MASTer switch for the renin-angiotensin system. J Clin Invest. 2006 Apr;116(4):866–9.
Le, Thu H., and Thomas M. Coffman. “A new cardiac MASTer switch for the renin-angiotensin system.J Clin Invest, vol. 116, no. 4, Apr. 2006, pp. 866–69. Pubmed, doi:10.1172/JCI28312.
Le TH, Coffman TM. A new cardiac MASTer switch for the renin-angiotensin system. J Clin Invest. 2006 Apr;116(4):866–869.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

April 2006

Volume

116

Issue

4

Start / End Page

866 / 869

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Renin
  • Myocardium
  • Mast Cells
  • Immunology
  • Humans
  • Cardiovascular Diseases
  • Blood Pressure
  • 42 Health sciences
  • 32 Biomedical and clinical sciences