A new cardiac MASTer switch for the renin-angiotensin system.
Publication
, Journal Article
Le, TH; Coffman, TM
Published in: J Clin Invest
April 2006
The aspartyl protease renin was first isolated from the kidney by Tigerstedt more than a century ago. In the kidney, renin secretion is tightly linked to sodium intake and renal perfusion pressure, reflecting the important role of the renin-angiotensin system (RAS) in controlling body fluid volume and blood pressure. The study by Mackins et al. in this issue of the JCI describes a novel source of renin: the mast cell (see the related article beginning on page 1063). This discovery suggests a distinct pathway for activation of the RAS that may have a particular impact on the pathogenesis of chronic tissue injury as well as more acute pathology such as arrhythmias in the heart.
Duke Scholars
Published In
J Clin Invest
DOI
ISSN
0021-9738
Publication Date
April 2006
Volume
116
Issue
4
Start / End Page
866 / 869
Location
United States
Related Subject Headings
- Renin-Angiotensin System
- Renin
- Myocardium
- Mast Cells
- Immunology
- Humans
- Cardiovascular Diseases
- Blood Pressure
- 42 Health sciences
- 32 Biomedical and clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Le, T. H., & Coffman, T. M. (2006). A new cardiac MASTer switch for the renin-angiotensin system. J Clin Invest, 116(4), 866–869. https://doi.org/10.1172/JCI28312
Le, Thu H., and Thomas M. Coffman. “A new cardiac MASTer switch for the renin-angiotensin system.” J Clin Invest 116, no. 4 (April 2006): 866–69. https://doi.org/10.1172/JCI28312.
Le TH, Coffman TM. A new cardiac MASTer switch for the renin-angiotensin system. J Clin Invest. 2006 Apr;116(4):866–9.
Le, Thu H., and Thomas M. Coffman. “A new cardiac MASTer switch for the renin-angiotensin system.” J Clin Invest, vol. 116, no. 4, Apr. 2006, pp. 866–69. Pubmed, doi:10.1172/JCI28312.
Le TH, Coffman TM. A new cardiac MASTer switch for the renin-angiotensin system. J Clin Invest. 2006 Apr;116(4):866–869.
Published In
J Clin Invest
DOI
ISSN
0021-9738
Publication Date
April 2006
Volume
116
Issue
4
Start / End Page
866 / 869
Location
United States
Related Subject Headings
- Renin-Angiotensin System
- Renin
- Myocardium
- Mast Cells
- Immunology
- Humans
- Cardiovascular Diseases
- Blood Pressure
- 42 Health sciences
- 32 Biomedical and clinical sciences