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Renal vein renins: inability to predict response to revascularization in patients with hypertension.

Publication ,  Journal Article
Roubidoux, MA; Dunnick, NR; Klotman, PE; Newman, GE; Cohan, RH; Kadir, S; Svetkey, LP
Published in: Radiology
March 1991

To determine whether the captopril-stimulated renal vein renin ratio (CSRVRR) could enable identification of patients with hemodynamically significant renovascular lesions who would respond to revascularization, the authors measured CSRVRRs in 143 consecutive patients with hypertension who had been selected because of clinical features suggestive of renovascular hypertension. All patients underwent conventional renal arteriography. Renovascular hypertension was the final diagnosis if revascularization resulted in cure or improvement in blood pressure. Complete data were available for 133 patients. Twenty patients had renovascular hypertension; CSRVRR was greater than 1.5 in 13 of these 20 patients (sensitivity, 65%). However, it was also greater than 1.5 in 54 of the 113 patients without renovascular hypertension (false-positive rate, 47.8%). The positive predictive value of CSRVRR was 18.6%; the negative predictive value, 89.3%. It is concluded that CSRVRR is not sufficiently sensitive to enable prediction of which patients will respond to revascularization and is not specific enough to exclude patients who do not have renovascular hypertension.

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Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

March 1991

Volume

178

Issue

3

Start / End Page

819 / 822

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Renin
  • Renal Veins
  • Prospective Studies
  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Hypertension, Renovascular
  • Humans
  • Clinical Enzyme Tests
 

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Roubidoux, M. A., Dunnick, N. R., Klotman, P. E., Newman, G. E., Cohan, R. H., Kadir, S., & Svetkey, L. P. (1991). Renal vein renins: inability to predict response to revascularization in patients with hypertension. Radiology, 178(3), 819–822. https://doi.org/10.1148/radiology.178.3.1994424
Roubidoux, M. A., N. R. Dunnick, P. E. Klotman, G. E. Newman, R. H. Cohan, S. Kadir, and L. P. Svetkey. “Renal vein renins: inability to predict response to revascularization in patients with hypertension.Radiology 178, no. 3 (March 1991): 819–22. https://doi.org/10.1148/radiology.178.3.1994424.
Roubidoux MA, Dunnick NR, Klotman PE, Newman GE, Cohan RH, Kadir S, et al. Renal vein renins: inability to predict response to revascularization in patients with hypertension. Radiology. 1991 Mar;178(3):819–22.
Roubidoux, M. A., et al. “Renal vein renins: inability to predict response to revascularization in patients with hypertension.Radiology, vol. 178, no. 3, Mar. 1991, pp. 819–22. Pubmed, doi:10.1148/radiology.178.3.1994424.
Roubidoux MA, Dunnick NR, Klotman PE, Newman GE, Cohan RH, Kadir S, Svetkey LP. Renal vein renins: inability to predict response to revascularization in patients with hypertension. Radiology. 1991 Mar;178(3):819–822.
Journal cover image

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

March 1991

Volume

178

Issue

3

Start / End Page

819 / 822

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Renin
  • Renal Veins
  • Prospective Studies
  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Hypertension, Renovascular
  • Humans
  • Clinical Enzyme Tests