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Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in rats.

Publication ,  Journal Article
Kim, CY; Kumar, A; Sampath, L; Sokol, K; Modak, S
Published in: Am J Kidney Dis
January 2002

Infection is the most serious complication arising in long-term continuous ambulatory peritoneal dialysis (CAPD), specifically peritonitis and exit-site infection. The initial weeks after implantation is the crucial period during which bacterial colonization of the catheter results in maximal morbidity, with Staphylococcus aureus being the most virulent organism. We developed an antimicrobial-impregnated CAPD catheter by impregnating the cuff and tubing with chlorhexidine, silver sulfadiazine, and triclosan in a polymer matrix. The antimicrobial spectrum and duration were shown by measuring zones of inhibition to various bacteria and fungi over the course of 5 to 10 days. Activity also was assessed subsequent to soaking in trypticase soy broth containing 20% bovine serum over the course of 1, 3, and 7 days. Significant antimicrobial activity was shown against all organisms tested for, with particular efficacy against gram-positive bacteria. Catheters were implanted in rats followed by inoculation of the exit site with S aureus. Seven days postimplantation, 0% of the impregnated catheters were colonized intraperitoneally compared with 100% of the control catheters. Similarly, 12.5% of the impregnated catheters were colonized at the exit site, whereas 100% of the controls were colonized. Histologic analysis showed that this combination and concentration of antimicrobials did not retard healing or cause increased inflammation compared with control catheters after 3, 10, and 24 days postimplantation in noninoculated rats.

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Published In

Am J Kidney Dis

DOI

EISSN

1523-6838

Publication Date

January 2002

Volume

39

Issue

1

Start / End Page

165 / 173

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Triclosan
  • Staphylococcus aureus
  • Staphylococcus
  • Silver Sulfadiazine
  • Rats, Sprague-Dawley
  • Rats
  • Prosthesis-Related Infections
  • Peritoneal Dialysis, Continuous Ambulatory
  • Microbial Sensitivity Tests
 

Citation

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MLA
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Kim, C. Y., Kumar, A., Sampath, L., Sokol, K., & Modak, S. (2002). Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in rats. Am J Kidney Dis, 39(1), 165–173. https://doi.org/10.1053/ajkd.2002.29911
Kim, Charles Y., Ashok Kumar, Lester Sampath, Karen Sokol, and Shanta Modak. “Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in rats.Am J Kidney Dis 39, no. 1 (January 2002): 165–73. https://doi.org/10.1053/ajkd.2002.29911.
Kim CY, Kumar A, Sampath L, Sokol K, Modak S. Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in rats. Am J Kidney Dis. 2002 Jan;39(1):165–73.
Kim, Charles Y., et al. “Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in rats.Am J Kidney Dis, vol. 39, no. 1, Jan. 2002, pp. 165–73. Pubmed, doi:10.1053/ajkd.2002.29911.
Kim CY, Kumar A, Sampath L, Sokol K, Modak S. Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in rats. Am J Kidney Dis. 2002 Jan;39(1):165–173.
Journal cover image

Published In

Am J Kidney Dis

DOI

EISSN

1523-6838

Publication Date

January 2002

Volume

39

Issue

1

Start / End Page

165 / 173

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Triclosan
  • Staphylococcus aureus
  • Staphylococcus
  • Silver Sulfadiazine
  • Rats, Sprague-Dawley
  • Rats
  • Prosthesis-Related Infections
  • Peritoneal Dialysis, Continuous Ambulatory
  • Microbial Sensitivity Tests