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Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: do children of all ages respond equally?

Publication ,  Journal Article
Walter, EB; Rajagopal, S; Zhu, Y; Neuzil, KM; Fairchok, MP; Englund, JA
Published in: Vaccine
June 17, 2010

We assessed the effect of age on immunogenicity to trivalent inactivated influenza vaccine (TIV) by comparing the immune responses to influenza vaccine antigens among three age cohorts of vaccine-naïve children aged 6-11 months, 12-17 months, and 18-23 months. In children 6-23 months of age, antibody responses to TIV appear to increase with increasing age. Despite this finding, TIV was immunogenic even in the youngest age group evaluated, further establishing its value as a tool to protect young children from influenza. The role of age should be considered when assessing improved vaccines to enhance TIV immunogenicity and effectiveness in younger children.

Duke Scholars

Published In

Vaccine

DOI

EISSN

1873-2518

Publication Date

June 17, 2010

Volume

28

Issue

27

Start / End Page

4376 / 4383

Location

Netherlands

Related Subject Headings

  • Virology
  • Sex Factors
  • Male
  • Influenza Vaccines
  • Infant
  • Humans
  • Female
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

Citation

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Chicago
ICMJE
MLA
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Walter, E. B., Rajagopal, S., Zhu, Y., Neuzil, K. M., Fairchok, M. P., & Englund, J. A. (2010). Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: do children of all ages respond equally? Vaccine, 28(27), 4376–4383. https://doi.org/10.1016/j.vaccine.2010.04.058
Walter, Emmanuel B., Shilpa Rajagopal, Yuwei Zhu, Kathleen M. Neuzil, Mary P. Fairchok, and Janet A. Englund. “Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: do children of all ages respond equally?Vaccine 28, no. 27 (June 17, 2010): 4376–83. https://doi.org/10.1016/j.vaccine.2010.04.058.
Walter EB, Rajagopal S, Zhu Y, Neuzil KM, Fairchok MP, Englund JA. Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: do children of all ages respond equally? Vaccine. 2010 Jun 17;28(27):4376–83.
Walter, Emmanuel B., et al. “Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: do children of all ages respond equally?Vaccine, vol. 28, no. 27, June 2010, pp. 4376–83. Pubmed, doi:10.1016/j.vaccine.2010.04.058.
Walter EB, Rajagopal S, Zhu Y, Neuzil KM, Fairchok MP, Englund JA. Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: do children of all ages respond equally? Vaccine. 2010 Jun 17;28(27):4376–4383.
Journal cover image

Published In

Vaccine

DOI

EISSN

1873-2518

Publication Date

June 17, 2010

Volume

28

Issue

27

Start / End Page

4376 / 4383

Location

Netherlands

Related Subject Headings

  • Virology
  • Sex Factors
  • Male
  • Influenza Vaccines
  • Infant
  • Humans
  • Female
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences