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Gastrin-releasing peptide, immune responses, and lung disease.

Publication ,  Journal Article
Degan, S; Lopez, GY; Kevill, K; Sunday, ME
Published in: Ann N Y Acad Sci
November 2008

Gastrin-releasing peptide (GRP) is produced by pulmonary neuroendocrine cells (PNECs), with highest numbers of GRP-positive cells present in fetal lung. Normally GRP-positive PNECs are relatively infrequent after birth, but PNEC hyperplasia is frequently associated with chronic lung diseases. To address the hypothesis that GRP mediates chronic lung injury, we present the cumulative evidence implicating GRP in bronchopulmonary dysplasia (BPD), the chronic lung disease of premature infants who survive acute respiratory distress syndrome. The availability of well-characterized animal models of BPD was a critical tool for demonstrating that GRP plays a direct role in the early pathogenesis of this disease. Potential mechanisms by which GRP contributes to injury are analyzed, with the main focus on innate immunity. Autoreactive T cells may contribute to lung injury late in the course of disease. A working model is proposed with GRP triggering multiple cell types in both the innate and adaptive immune systems, promoting cascades culminating in chronic lung disease. These observations represent a paradigm shift in the understanding of the early pathogenesis of BPD, and suggest that GRP blockade could be a novel treatment to prevent this lung disease in premature infants.

Duke Scholars

Published In

Ann N Y Acad Sci

DOI

EISSN

1749-6632

Publication Date

November 2008

Volume

1144

Start / End Page

136 / 147

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Models, Biological
  • Lung Diseases
  • Infant, Newborn
  • Immunity, Innate
  • Immune System Phenomena
  • Humans
  • General Science & Technology
  • Gastrin-Releasing Peptide
  • Bronchopulmonary Dysplasia
 

Citation

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ICMJE
MLA
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Degan, S., Lopez, G. Y., Kevill, K., & Sunday, M. E. (2008). Gastrin-releasing peptide, immune responses, and lung disease. Ann N Y Acad Sci, 1144, 136–147. https://doi.org/10.1196/annals.1418.022
Degan, Simone, Giselle Y. Lopez, Katharine Kevill, and Mary E. Sunday. “Gastrin-releasing peptide, immune responses, and lung disease.Ann N Y Acad Sci 1144 (November 2008): 136–47. https://doi.org/10.1196/annals.1418.022.
Degan S, Lopez GY, Kevill K, Sunday ME. Gastrin-releasing peptide, immune responses, and lung disease. Ann N Y Acad Sci. 2008 Nov;1144:136–47.
Degan, Simone, et al. “Gastrin-releasing peptide, immune responses, and lung disease.Ann N Y Acad Sci, vol. 1144, Nov. 2008, pp. 136–47. Pubmed, doi:10.1196/annals.1418.022.
Degan S, Lopez GY, Kevill K, Sunday ME. Gastrin-releasing peptide, immune responses, and lung disease. Ann N Y Acad Sci. 2008 Nov;1144:136–147.
Journal cover image

Published In

Ann N Y Acad Sci

DOI

EISSN

1749-6632

Publication Date

November 2008

Volume

1144

Start / End Page

136 / 147

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Models, Biological
  • Lung Diseases
  • Infant, Newborn
  • Immunity, Innate
  • Immune System Phenomena
  • Humans
  • General Science & Technology
  • Gastrin-Releasing Peptide
  • Bronchopulmonary Dysplasia