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Rapid noninvasive optical imaging of tissue composition in breast tumor margins.

Publication ,  Journal Article
Wilke, LG; Brown, JQ; Bydlon, TM; Kennedy, SA; Richards, LM; Junker, MK; Gallagher, J; Barry, WT; Geradts, J; Ramanujam, N
Published in: Am J Surg
October 2009

BACKGROUND: In women undergoing breast conserving surgery (BCS), up to 60% can require re-excision. Our objective is to develop an optically based technology which can differentiate benign from malignant breast tissues intraoperatively through differences in tissue composition factors. METHODS: A prospective study of optical imaging of BCS margins is being performed. Optical images are transformed into tissue composition maps with parameters of total hemoglobin concentration, b-carotene concentration and scattering. The predicted outcome is then compared to the margin-level pathology. RESULTS: Fifty-five margins from 48 patients have undergone assessment. Within 34 specimens with pathologically confirmed positive margins, the ratio map of b-carotene/scattering showed the most significant difference reflecting a decrease in adipose and an increase in cell density within malignant margins (p=.002). These differences were notable in both in-situ and invasive disease. CONCLUSIONS: We present a novel optical spectral imaging device that provides a rapid, non-destructive assay of the tissue composition of breast tumor margins.

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Published In

Am J Surg

DOI

EISSN

1879-1883

Publication Date

October 2009

Volume

198

Issue

4

Start / End Page

566 / 574

Location

United States

Related Subject Headings

  • Surgery
  • Spectrum Analysis
  • Reoperation
  • Predictive Value of Tests
  • Optical Devices
  • Mastectomy, Segmental
  • Humans
  • Female
  • Breast Neoplasms
  • 3203 Dentistry
 

Citation

APA
Chicago
ICMJE
MLA
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Wilke, L. G., Brown, J. Q., Bydlon, T. M., Kennedy, S. A., Richards, L. M., Junker, M. K., … Ramanujam, N. (2009). Rapid noninvasive optical imaging of tissue composition in breast tumor margins. Am J Surg, 198(4), 566–574. https://doi.org/10.1016/j.amjsurg.2009.06.018
Wilke, Lee G., J Quincy Brown, Torre M. Bydlon, Stephanie A. Kennedy, Lisa M. Richards, Marlee K. Junker, Jennifer Gallagher, William T. Barry, Joseph Geradts, and Nimmi Ramanujam. “Rapid noninvasive optical imaging of tissue composition in breast tumor margins.Am J Surg 198, no. 4 (October 2009): 566–74. https://doi.org/10.1016/j.amjsurg.2009.06.018.
Wilke LG, Brown JQ, Bydlon TM, Kennedy SA, Richards LM, Junker MK, et al. Rapid noninvasive optical imaging of tissue composition in breast tumor margins. Am J Surg. 2009 Oct;198(4):566–74.
Wilke, Lee G., et al. “Rapid noninvasive optical imaging of tissue composition in breast tumor margins.Am J Surg, vol. 198, no. 4, Oct. 2009, pp. 566–74. Pubmed, doi:10.1016/j.amjsurg.2009.06.018.
Wilke LG, Brown JQ, Bydlon TM, Kennedy SA, Richards LM, Junker MK, Gallagher J, Barry WT, Geradts J, Ramanujam N. Rapid noninvasive optical imaging of tissue composition in breast tumor margins. Am J Surg. 2009 Oct;198(4):566–574.
Journal cover image

Published In

Am J Surg

DOI

EISSN

1879-1883

Publication Date

October 2009

Volume

198

Issue

4

Start / End Page

566 / 574

Location

United States

Related Subject Headings

  • Surgery
  • Spectrum Analysis
  • Reoperation
  • Predictive Value of Tests
  • Optical Devices
  • Mastectomy, Segmental
  • Humans
  • Female
  • Breast Neoplasms
  • 3203 Dentistry