Multicenter studies of tigecycline disk diffusion susceptibility results for Acinetobacter spp.
Acinetobacter sp. isolates having multidrug resistance (MDR) patterns have become common in many medical centers worldwide, limiting therapeutic options. A five-center study tested 103 contemporary clinical Acinetobacter spp., including MDR strains, by reference broth microdilution and disk diffusion (15-mug disk content) methods against tigecycline. Applying U.S. Food and Drug Administration tigecycline breakpoint criteria for Enterobacteriaceae (susceptibility at < or =2 microg/ml [< or =1 microg/ml by the European Committee on Antimicrobial Susceptibility Testing]; disk diffusion breakpoints at > or =19 mm and < or =14 mm) to Acinetobacter spp. led to an unacceptable error rate (23.3%). However, an adjustment of tigecycline disk diffusion breakpoints (susceptible/resistant) to > or =16/ < or =12 mm reduced intermethod errors to an acceptable level (only 9.7%, all minor).
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Related Subject Headings
- Tigecycline
- Minocycline
- Microbiology
- Microbial Sensitivity Tests
- Humans
- Drug Resistance, Multiple, Bacterial
- Anti-Bacterial Agents
- Acinetobacter Infections
- Acinetobacter
- 3207 Medical microbiology
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tigecycline
- Minocycline
- Microbiology
- Microbial Sensitivity Tests
- Humans
- Drug Resistance, Multiple, Bacterial
- Anti-Bacterial Agents
- Acinetobacter Infections
- Acinetobacter
- 3207 Medical microbiology