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Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women.

Publication ,  Journal Article
Moorman, PG; Calingaert, B; Palmieri, RT; Iversen, ES; Bentley, RC; Halabi, S; Berchuck, A; Schildkraut, JM
Published in: Am J Epidemiol
May 1, 2008

Ovarian cancer is most frequently diagnosed in postmenopausal women; however, the strongest risk predictors, pregnancy and oral contraceptive use, occur in most women in their twenties and thirties. Relatively few studies have examined how reproductive risk factors vary between pre- and postmenopausal ovarian cancer. The authors used data from a population-based, case-control study of ovarian cancer (896 cases, 967 controls) conducted in North Carolina from 1999 to 2006. Odds ratios and 95% confidence intervals were calculated by using unconditional logistic regression. Inverse associations with ovarian cancer were observed with duration of oral contraceptive use, later age at last use, and more recent use among premenopausal women; no significant associations were found for postmenopausal women. Analyses limited to oral contraceptive users showed that duration was a more significant predictor of risk than was timing of use. Parity was inversely associated with premenopausal but not postmenopausal ovarian cancer. Later age at pregnancy was associated with reduced risk for both pre- and postmenopausal women. Analyses among parous women showed that pregnancy timing was a stronger risk predictor than number of pregnancies. Findings suggest that associations between ovarian cancer and reproductive characteristics vary by menopausal status. Additional research is needed to further elucidate risk factors for postmenopausal disease.

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Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

May 1, 2008

Volume

167

Issue

9

Start / End Page

1059 / 1069

Location

United States

Related Subject Headings

  • Risk Factors
  • Registries
  • Premenopause
  • Pregnancy
  • Postmenopause
  • Parity
  • Ovarian Neoplasms
  • North Carolina
  • Middle Aged
  • Logistic Models
 

Citation

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Chicago
ICMJE
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Moorman, P. G., Calingaert, B., Palmieri, R. T., Iversen, E. S., Bentley, R. C., Halabi, S., … Schildkraut, J. M. (2008). Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women. Am J Epidemiol, 167(9), 1059–1069. https://doi.org/10.1093/aje/kwn006
Moorman, Patricia G., Brian Calingaert, Rachel T. Palmieri, Edwin S. Iversen, Rex C. Bentley, Susan Halabi, Andrew Berchuck, and Joellen M. Schildkraut. “Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women.Am J Epidemiol 167, no. 9 (May 1, 2008): 1059–69. https://doi.org/10.1093/aje/kwn006.
Moorman PG, Calingaert B, Palmieri RT, Iversen ES, Bentley RC, Halabi S, et al. Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women. Am J Epidemiol. 2008 May 1;167(9):1059–69.
Moorman, Patricia G., et al. “Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women.Am J Epidemiol, vol. 167, no. 9, May 2008, pp. 1059–69. Pubmed, doi:10.1093/aje/kwn006.
Moorman PG, Calingaert B, Palmieri RT, Iversen ES, Bentley RC, Halabi S, Berchuck A, Schildkraut JM. Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women. Am J Epidemiol. 2008 May 1;167(9):1059–1069.
Journal cover image

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

May 1, 2008

Volume

167

Issue

9

Start / End Page

1059 / 1069

Location

United States

Related Subject Headings

  • Risk Factors
  • Registries
  • Premenopause
  • Pregnancy
  • Postmenopause
  • Parity
  • Ovarian Neoplasms
  • North Carolina
  • Middle Aged
  • Logistic Models