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In vivo study of microvascular wall characteristics and resting control in young and mature spontaneously hypertensive rats.

Publication ,  Journal Article
Bohlen, HG; Lobach, D
Published in: Blood Vessels
1978

This study was designed to determine if vessel wall hypertrophy and increased expression of sympathetic activity occur in the microcirculation during the development of hypertension. The cremaster muscle microvasculature of normal Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats was observed at age 5--7 weeks and 16--18 weeks. For age-matched WKY and SHR rats, the diameters, wall thicknesses and vessel wall cross-sectional areas for the majority of comparable types of arterioles were not significantly (p greater than 0.05) different. After denervation of the cremasteric muscle, the large and intermediate diameter arterioles of young WKY rats dilated significantly (p less than 0.05) more than did comparable vessels of SHR rats. In contrast, the dilation of comparable types of arterioles in mature WKY and SHR rats following denervation was not significantly (p greater than 0.05) different. The results do not support either abnormal vessel wall hypertrophy, vasoconstriction or increased expression of sympathetic activity in SHR rats compared to WKY rats up to age 16--18 weeks.

Duke Scholars

Published In

Blood Vessels

DOI

ISSN

0303-6847

Publication Date

1978

Volume

15

Issue

5

Start / End Page

322 / 330

Location

Switzerland

Related Subject Headings

  • Vascular Resistance
  • Rats
  • Microcirculation
  • Male
  • Hypertrophy
  • Hypertension
  • Arterioles
  • Animals
 

Citation

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Bohlen, H. G., & Lobach, D. (1978). In vivo study of microvascular wall characteristics and resting control in young and mature spontaneously hypertensive rats. Blood Vessels, 15(5), 322–330. https://doi.org/10.1159/000158177
Bohlen, H. G., and D. Lobach. “In vivo study of microvascular wall characteristics and resting control in young and mature spontaneously hypertensive rats.Blood Vessels 15, no. 5 (1978): 322–30. https://doi.org/10.1159/000158177.
Bohlen, H. G., and D. Lobach. “In vivo study of microvascular wall characteristics and resting control in young and mature spontaneously hypertensive rats.Blood Vessels, vol. 15, no. 5, 1978, pp. 322–30. Pubmed, doi:10.1159/000158177.

Published In

Blood Vessels

DOI

ISSN

0303-6847

Publication Date

1978

Volume

15

Issue

5

Start / End Page

322 / 330

Location

Switzerland

Related Subject Headings

  • Vascular Resistance
  • Rats
  • Microcirculation
  • Male
  • Hypertrophy
  • Hypertension
  • Arterioles
  • Animals