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Antiplatelet therapy in pediatric cardiovascular patients.

Publication ,  Journal Article
Li, JS; Newburger, JW
Published in: Pediatr Cardiol
May 2010

Platelets play a critical role in normal physiologic processes such as hemostasis, wound healing, inflammation, and innate immunity. However, they also play a role in the pathologic process of thrombosis. Although antiplatelet therapy is most commonly used to prevent thrombotic events for adults with atherosclerotic vascular disease, children with certain types of congenital heart disease, stroke, and Kawasaki disease also are at risk for thrombosis and may benefit from antiplatelet therapy. Unfortunately, very little data on the efficacy and safety of antiplatelet therapy for pediatric patients are available. As a consequence, consistent clinical practice among pediatric practitioners is lacking. Furthermore, much of what is practiced results from extrapolation from adult studies, which may be problematic because many aspects of platelet biology differ between children and adults. This review discusses aspects of antiplatelet therapy for pediatric patients.

Duke Scholars

Published In

Pediatr Cardiol

DOI

EISSN

1432-1971

Publication Date

May 2010

Volume

31

Issue

4

Start / End Page

454 / 461

Location

United States

Related Subject Headings

  • Thrombosis
  • Thrombophilia
  • Risk Factors
  • Postoperative Complications
  • Platelet Function Tests
  • Platelet Aggregation Inhibitors
  • Humans
  • Heart Defects, Congenital
  • Cerebral Infarction
  • Cardiovascular System & Hematology
 

Citation

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MLA
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Li, J. S., & Newburger, J. W. (2010). Antiplatelet therapy in pediatric cardiovascular patients. Pediatr Cardiol, 31(4), 454–461. https://doi.org/10.1007/s00246-010-9672-2
Li, Jennifer S., and Jane W. Newburger. “Antiplatelet therapy in pediatric cardiovascular patients.Pediatr Cardiol 31, no. 4 (May 2010): 454–61. https://doi.org/10.1007/s00246-010-9672-2.
Li JS, Newburger JW. Antiplatelet therapy in pediatric cardiovascular patients. Pediatr Cardiol. 2010 May;31(4):454–61.
Li, Jennifer S., and Jane W. Newburger. “Antiplatelet therapy in pediatric cardiovascular patients.Pediatr Cardiol, vol. 31, no. 4, May 2010, pp. 454–61. Pubmed, doi:10.1007/s00246-010-9672-2.
Li JS, Newburger JW. Antiplatelet therapy in pediatric cardiovascular patients. Pediatr Cardiol. 2010 May;31(4):454–461.
Journal cover image

Published In

Pediatr Cardiol

DOI

EISSN

1432-1971

Publication Date

May 2010

Volume

31

Issue

4

Start / End Page

454 / 461

Location

United States

Related Subject Headings

  • Thrombosis
  • Thrombophilia
  • Risk Factors
  • Postoperative Complications
  • Platelet Function Tests
  • Platelet Aggregation Inhibitors
  • Humans
  • Heart Defects, Congenital
  • Cerebral Infarction
  • Cardiovascular System & Hematology