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Birth weight and prematurity in infants with single ventricle physiology: pediatric heart network infant single ventricle trial screened population.

Publication ,  Journal Article
Williams, RV; Ravishankar, C; Zak, V; Evans, F; Atz, AM; Border, WL; Levine, J; Li, JS; Mahony, L; Mital, S; Pearson, GD; Prakash, A; Hsu, DT ...
Published in: Congenit Heart Dis
2010

OBJECTIVES: Although congenital heart disease is associated with low birth weight and prematurity, there is little information about these birth outcomes in infants with single ventricle physiology. We describe the birth outcomes (i.e., gestational age and birth weight) in neonates with single ventricle physiology screened for enrollment in the Pediatric Heart Network's Infant Single Ventricle Trial, compare these outcomes with US norms, and examine the association of birth outcomes with anatomic diagnosis and race. PATIENTS AND METHODS: All neonates with single ventricle physiology presenting to Infant Single Ventricle Trial centers were screened for enrollment. Demographic data and anatomic diagnoses were obtained from medical records. RESULTS: A total of 1245 neonates with single ventricle physiology were screened at 10 centers (63 to 266 per center). Diagnoses included hypoplastic left heart syndrome in 49%, unbalanced atrioventricular septal defect in 12%, and tricuspid atresia in 9%. Preterm birth occurred in 16% of neonates with single ventricle physiology vs. 12% in normal neonates (P < .001), low birth weight (<2.5 kg) in 18% vs. 8% in normals (P < .001), and small for gestational age (<10th percentile by definition) in 22% vs. 10% in normals (P < .001). A genetic syndrome was reported in 8%. The percentage of preterm birth, low birth weight, and small for gestational age was similar between screened neonates with and without hypoplastic left heart syndrome. CONCLUSIONS: In this large, contemporary cohort of neonates with single ventricle physiology, rates of preterm birth, low birth weight, and small for gestational age were higher than in the general population, but similar between screened neonates with and without hypoplastic left heart syndrome.

Duke Scholars

Published In

Congenit Heart Dis

DOI

EISSN

1747-0803

Publication Date

2010

Volume

5

Issue

2

Start / End Page

96 / 103

Location

United States

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Male
  • Infant, Small for Gestational Age
  • Infant, Premature
  • Infant, Newborn
  • Infant, Low Birth Weight
  • Humans
  • Heart Ventricles
  • Heart Defects, Congenital
  • Gestational Age
 

Citation

APA
Chicago
ICMJE
MLA
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Williams, R. V., Ravishankar, C., Zak, V., Evans, F., Atz, A. M., Border, W. L., … Pediatric Heart Network Investigators, . (2010). Birth weight and prematurity in infants with single ventricle physiology: pediatric heart network infant single ventricle trial screened population. Congenit Heart Dis, 5(2), 96–103. https://doi.org/10.1111/j.1747-0803.2009.00369.x
Williams, Richard V., Chitra Ravishankar, Victor Zak, Frank Evans, Andrew M. Atz, William L. Border, Jami Levine, et al. “Birth weight and prematurity in infants with single ventricle physiology: pediatric heart network infant single ventricle trial screened population.Congenit Heart Dis 5, no. 2 (2010): 96–103. https://doi.org/10.1111/j.1747-0803.2009.00369.x.
Williams RV, Ravishankar C, Zak V, Evans F, Atz AM, Border WL, et al. Birth weight and prematurity in infants with single ventricle physiology: pediatric heart network infant single ventricle trial screened population. Congenit Heart Dis. 2010;5(2):96–103.
Williams, Richard V., et al. “Birth weight and prematurity in infants with single ventricle physiology: pediatric heart network infant single ventricle trial screened population.Congenit Heart Dis, vol. 5, no. 2, 2010, pp. 96–103. Pubmed, doi:10.1111/j.1747-0803.2009.00369.x.
Williams RV, Ravishankar C, Zak V, Evans F, Atz AM, Border WL, Levine J, Li JS, Mahony L, Mital S, Pearson GD, Prakash A, Hsu DT, Pediatric Heart Network Investigators. Birth weight and prematurity in infants with single ventricle physiology: pediatric heart network infant single ventricle trial screened population. Congenit Heart Dis. 2010;5(2):96–103.
Journal cover image

Published In

Congenit Heart Dis

DOI

EISSN

1747-0803

Publication Date

2010

Volume

5

Issue

2

Start / End Page

96 / 103

Location

United States

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Male
  • Infant, Small for Gestational Age
  • Infant, Premature
  • Infant, Newborn
  • Infant, Low Birth Weight
  • Humans
  • Heart Ventricles
  • Heart Defects, Congenital
  • Gestational Age