Skip to main content
Journal cover image

The coenrichment of stem cells, prothymocytes, and stromal elements with ecotropic retrovirus-producing cells from the bone marrow of leukemia-prone AKR mice.

Publication ,  Journal Article
Buckheit, RW; Kurtzberg, J; Bolognesi, DP; Weinhold, KJ
Published in: Virology
February 1988

Ecotropic virus-producing cells in the bone marrow of the leukemia-prone AKR strain of mice were significantly enriched by fractionation on discontinuous density gradients of Percoll and were found in a low-density population of cells comprised predominantly of medium to large blast cells. The high ecotropic virus-producing low-density bone marrow cell population was also found to be significantly enriched in pluripotent stem cells, prothymocytes, and stromal elements. During the period of time defined by a window for successful leukemosuppressive immunotherapy of AKR mice, virus-producing cells were exclusively detected in this fraction of bone marrow cells, implicating the functional classes of cells coenriched in this fraction as both potential targets of anti-viral immunotherapy and responsible for the seeding of the spleen and thymus with infectious ecotropic virus.

Duke Scholars

Published In

Virology

DOI

ISSN

0042-6822

Publication Date

February 1988

Volume

162

Issue

2

Start / End Page

354 / 361

Location

United States

Related Subject Headings

  • Virology
  • Viral Proteins
  • Thymus Gland
  • Stem Cells
  • Phenotype
  • Mice, Inbred AKR
  • Mice
  • Leukemia Virus, Murine
  • Cell Separation
  • Bone Marrow Cells
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Buckheit, R. W., Kurtzberg, J., Bolognesi, D. P., & Weinhold, K. J. (1988). The coenrichment of stem cells, prothymocytes, and stromal elements with ecotropic retrovirus-producing cells from the bone marrow of leukemia-prone AKR mice. Virology, 162(2), 354–361. https://doi.org/10.1016/0042-6822(88)90475-8
Buckheit, R. W., J. Kurtzberg, D. P. Bolognesi, and K. J. Weinhold. “The coenrichment of stem cells, prothymocytes, and stromal elements with ecotropic retrovirus-producing cells from the bone marrow of leukemia-prone AKR mice.Virology 162, no. 2 (February 1988): 354–61. https://doi.org/10.1016/0042-6822(88)90475-8.
Buckheit, R. W., et al. “The coenrichment of stem cells, prothymocytes, and stromal elements with ecotropic retrovirus-producing cells from the bone marrow of leukemia-prone AKR mice.Virology, vol. 162, no. 2, Feb. 1988, pp. 354–61. Pubmed, doi:10.1016/0042-6822(88)90475-8.
Journal cover image

Published In

Virology

DOI

ISSN

0042-6822

Publication Date

February 1988

Volume

162

Issue

2

Start / End Page

354 / 361

Location

United States

Related Subject Headings

  • Virology
  • Viral Proteins
  • Thymus Gland
  • Stem Cells
  • Phenotype
  • Mice, Inbred AKR
  • Mice
  • Leukemia Virus, Murine
  • Cell Separation
  • Bone Marrow Cells