A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling.
Publication
, Journal Article
Zhou, J; Soontornworajit, B; Martin, J; Sullenger, BA; Gilboa, E; Wang, Y
Published in: Macromol Biosci
September 9, 2009
Antibodies are natural nanomaterials and have been widely used for targeted cell labeling. However, the applications of antibodies are often limited by their large size and instability. The purpose of this study is to develop a new type of multifunctional nanomaterial that is comprised of a nucleic acid aptamer and a dendrimer, both of which are stable. This nanomaterial is approximately 8 nm in size. Moreover, it could not only carry multiple signal molecules, but also bind to target cancer cells with high affinity and specificity. This sub-10 nm multifunctional nanomaterial is expected to be useful in basic biomedical research and clinical medicine.
Duke Scholars
Published In
Macromol Biosci
DOI
EISSN
1616-5195
Publication Date
September 9, 2009
Volume
9
Issue
9
Start / End Page
831 / 835
Location
Germany
Related Subject Headings
- Staining and Labeling
- SELEX Aptamer Technique
- Polymers
- Polyamines
- Particle Size
- Nucleic Acid Conformation
- Nanostructures
- Molecular Structure
- Humans
- Dendrimers
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhou, J., Soontornworajit, B., Martin, J., Sullenger, B. A., Gilboa, E., & Wang, Y. (2009). A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling. Macromol Biosci, 9(9), 831–835. https://doi.org/10.1002/mabi.200900046
Zhou, Jing, Boonchoy Soontornworajit, Jacob Martin, Bruce A. Sullenger, Eli Gilboa, and Yong Wang. “A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling.” Macromol Biosci 9, no. 9 (September 9, 2009): 831–35. https://doi.org/10.1002/mabi.200900046.
Zhou J, Soontornworajit B, Martin J, Sullenger BA, Gilboa E, Wang Y. A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling. Macromol Biosci. 2009 Sep 9;9(9):831–5.
Zhou, Jing, et al. “A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling.” Macromol Biosci, vol. 9, no. 9, Sept. 2009, pp. 831–35. Pubmed, doi:10.1002/mabi.200900046.
Zhou J, Soontornworajit B, Martin J, Sullenger BA, Gilboa E, Wang Y. A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling. Macromol Biosci. 2009 Sep 9;9(9):831–835.
Published In
Macromol Biosci
DOI
EISSN
1616-5195
Publication Date
September 9, 2009
Volume
9
Issue
9
Start / End Page
831 / 835
Location
Germany
Related Subject Headings
- Staining and Labeling
- SELEX Aptamer Technique
- Polymers
- Polyamines
- Particle Size
- Nucleic Acid Conformation
- Nanostructures
- Molecular Structure
- Humans
- Dendrimers