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Development of universal antidotes to control aptamer activity.

Publication ,  Journal Article
Oney, S; Lam, RTS; Bompiani, KM; Blake, CM; Quick, G; Heidel, JD; Liu, JY-C; Mack, BC; Davis, ME; Leong, KW; Sullenger, BA
Published in: Nat Med
October 2009

With an ever increasing number of people taking numerous medications, the need to safely administer drugs and limit unintended side effects has never been greater. Antidote control remains the most direct means to counteract acute side effects of drugs, but, unfortunately, it has been challenging and cost prohibitive to generate antidotes for most therapeutic agents. Here we describe the development of a set of antidote molecules that are capable of counteracting the effects of an entire class of therapeutic agents based upon aptamers. These universal antidotes exploit the fact that, when systemically administered, aptamers are the only free extracellular oligonucleotides found in circulation. We show that protein- and polymer-based molecules that capture oligonucleotides can reverse the activity of several aptamers in vitro and counteract aptamer activity in vivo. The availability of universal antidotes to control the activity of any aptamer suggests that aptamers may be a particularly safe class of therapeutics.

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Published In

Nat Med

DOI

EISSN

1546-170X

Publication Date

October 2009

Volume

15

Issue

10

Start / End Page

1224 / 1228

Location

United States

Related Subject Headings

  • Time Factors
  • Protamines
  • Oligonucleotides
  • Nucleic Acid Conformation
  • Immunology
  • Humans
  • Factor Xa Inhibitors
  • Factor IX
  • Drug Design
  • Drug Delivery Systems
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Oney, S., Lam, R. T. S., Bompiani, K. M., Blake, C. M., Quick, G., Heidel, J. D., … Sullenger, B. A. (2009). Development of universal antidotes to control aptamer activity. Nat Med, 15(10), 1224–1228. https://doi.org/10.1038/nm.1990
Oney, Sabah, Ruby T. S. Lam, Kristin M. Bompiani, Charlene M. Blake, George Quick, Jeremy D. Heidel, Joanna Yi-Ching Liu, et al. “Development of universal antidotes to control aptamer activity.Nat Med 15, no. 10 (October 2009): 1224–28. https://doi.org/10.1038/nm.1990.
Oney S, Lam RTS, Bompiani KM, Blake CM, Quick G, Heidel JD, et al. Development of universal antidotes to control aptamer activity. Nat Med. 2009 Oct;15(10):1224–8.
Oney, Sabah, et al. “Development of universal antidotes to control aptamer activity.Nat Med, vol. 15, no. 10, Oct. 2009, pp. 1224–28. Pubmed, doi:10.1038/nm.1990.
Oney S, Lam RTS, Bompiani KM, Blake CM, Quick G, Heidel JD, Liu JY-C, Mack BC, Davis ME, Leong KW, Sullenger BA. Development of universal antidotes to control aptamer activity. Nat Med. 2009 Oct;15(10):1224–1228.

Published In

Nat Med

DOI

EISSN

1546-170X

Publication Date

October 2009

Volume

15

Issue

10

Start / End Page

1224 / 1228

Location

United States

Related Subject Headings

  • Time Factors
  • Protamines
  • Oligonucleotides
  • Nucleic Acid Conformation
  • Immunology
  • Humans
  • Factor Xa Inhibitors
  • Factor IX
  • Drug Design
  • Drug Delivery Systems