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X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses.

Publication ,  Journal Article
Bassiri, H; Janice Yeo, WC; Rothman, J; Koretzky, GA; Nichols, KE
Published in: Immunol Res
2008

A major focus of our research is to understand the molecular and cellular basis of X-linked lymphoproliferative disease (XLP), a rare and often fatal immunodeficiency caused by mutations in the SH2D1A gene, which encodes the adaptor molecule SAP. Recently, we observed that SAP is essential for the development of natural killer T (NKT) cells, a lymphocyte population that participates in protection against certain tumors, infections, and autoimmune states. In this review, we describe the approaches that we are taking to understand the role of SAP in immune cells, including NKT cells. By using SAP as the focal point of our studies, we hope to identify novel signaling pathways that could be targeted to improve the treatment for patients with XLP as well as more common disorders, such as autoimmunity and cancer.

Duke Scholars

Published In

Immunol Res

DOI

ISSN

0257-277X

Publication Date

2008

Volume

42

Issue

1-3

Start / End Page

145 / 159

Location

United States

Related Subject Headings

  • Virus Diseases
  • T-Lymphocytes
  • Signaling Lymphocytic Activation Molecule Associated Protein
  • Neoplasms
  • Mutation
  • Lymphoproliferative Disorders
  • Killer Cells, Natural
  • Intracellular Signaling Peptides and Proteins
  • Immunology
  • Humans
 

Citation

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Bassiri, H., Janice Yeo, W. C., Rothman, J., Koretzky, G. A., & Nichols, K. E. (2008). X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. Immunol Res, 42(1–3), 145–159. https://doi.org/10.1007/s12026-008-8048-7
Bassiri, Hamid, W. C. Janice Yeo, Jennifer Rothman, Gary A. Koretzky, and Kim E. Nichols. “X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses.Immunol Res 42, no. 1–3 (2008): 145–59. https://doi.org/10.1007/s12026-008-8048-7.
Bassiri H, Janice Yeo WC, Rothman J, Koretzky GA, Nichols KE. X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. Immunol Res. 2008;42(1–3):145–59.
Bassiri, Hamid, et al. “X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses.Immunol Res, vol. 42, no. 1–3, 2008, pp. 145–59. Pubmed, doi:10.1007/s12026-008-8048-7.
Bassiri H, Janice Yeo WC, Rothman J, Koretzky GA, Nichols KE. X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. Immunol Res. 2008;42(1–3):145–159.
Journal cover image

Published In

Immunol Res

DOI

ISSN

0257-277X

Publication Date

2008

Volume

42

Issue

1-3

Start / End Page

145 / 159

Location

United States

Related Subject Headings

  • Virus Diseases
  • T-Lymphocytes
  • Signaling Lymphocytic Activation Molecule Associated Protein
  • Neoplasms
  • Mutation
  • Lymphoproliferative Disorders
  • Killer Cells, Natural
  • Intracellular Signaling Peptides and Proteins
  • Immunology
  • Humans