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Thoracoscopic lobectomy facilitates the delivery of chemotherapy after resection for lung cancer.

Publication ,  Journal Article
Petersen, RP; Pham, D; Burfeind, WR; Hanish, SI; Toloza, EM; Harpole, DH; D'Amico, TA
Published in: Ann Thorac Surg
April 2007

BACKGROUND: We conducted a study of patients who underwent anatomic resection with adjuvant chemotherapy to determine if thoracoscopic lobectomy enables more effective administration of adjuvant chemotherapy than lobectomy by thoracotomy. METHODS: We reviewed the outcomes of 100 consecutive patients with non-small cell lung cancer (NSCLC) who underwent lobectomy and received adjuvant chemotherapy (1999 to 2004). The variables analyzed were time to initiation of chemotherapy, percentage of planned regimen received, number of delayed or reduced chemotherapy doses, toxicity grade, length of hospitalization, chest tube duration, 30-day mortality, and major complications (pneumonia, respiratory failure, atrial fibrillation). The chi2 test and Student t test were used to compare dichotomous and continuous variables, respectively. RESULTS: Complete resection was performed by thoracotomy in 43 patients and by thoracoscopy in 57 (no conversions). All patients received adjuvant chemotherapy, and 20 (20%) received adjuvant radiation therapy: 13 (30%) of 43 in the thoracotomy group and 7 (12%) of 57 in the thoracoscopy group (p = 0.04). Patients undergoing thoracoscopic lobectomy had significantly fewer delayed (18% versus 58%, p < 0.001) and reduced (26% versus 49%, p = 0.02) chemotherapy doses. A higher percentage of patients undergoing thoracoscopic resection received 75% or more of their planned adjuvant regimen without delayed or reduced doses (61% versus 40%, p = 0.03). There were no significant differences in time to initiation of chemotherapy or toxicity. Patients undergoing a thoracoscopic lobectomy had a shorter median length of hospitalization (4 days versus 5 days, p = 0.02). CONCLUSIONS: Thoracoscopy was associated with an overall higher compliance rate and fewer delayed or reduced doses of chemotherapy in patients receiving adjuvant chemotherapy.

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Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

April 2007

Volume

83

Issue

4

Start / End Page

1245 / 1249

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Thoracotomy
  • Thoracoscopy
  • Survival Analysis
  • Statistics, Nonparametric
  • Risk Assessment
  • Retrospective Studies
  • Respiratory System
  • Prognosis
  • Probability
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Petersen, R. P., Pham, D., Burfeind, W. R., Hanish, S. I., Toloza, E. M., Harpole, D. H., & D’Amico, T. A. (2007). Thoracoscopic lobectomy facilitates the delivery of chemotherapy after resection for lung cancer. Ann Thorac Surg, 83(4), 1245–1249. https://doi.org/10.1016/j.athoracsur.2006.12.029
Petersen, Rebecca P., DuyKhanh Pham, William R. Burfeind, Steven I. Hanish, Eric M. Toloza, David H. Harpole, and Thomas A. D’Amico. “Thoracoscopic lobectomy facilitates the delivery of chemotherapy after resection for lung cancer.Ann Thorac Surg 83, no. 4 (April 2007): 1245–49. https://doi.org/10.1016/j.athoracsur.2006.12.029.
Petersen RP, Pham D, Burfeind WR, Hanish SI, Toloza EM, Harpole DH, et al. Thoracoscopic lobectomy facilitates the delivery of chemotherapy after resection for lung cancer. Ann Thorac Surg. 2007 Apr;83(4):1245–9.
Petersen, Rebecca P., et al. “Thoracoscopic lobectomy facilitates the delivery of chemotherapy after resection for lung cancer.Ann Thorac Surg, vol. 83, no. 4, Apr. 2007, pp. 1245–49. Pubmed, doi:10.1016/j.athoracsur.2006.12.029.
Petersen RP, Pham D, Burfeind WR, Hanish SI, Toloza EM, Harpole DH, D’Amico TA. Thoracoscopic lobectomy facilitates the delivery of chemotherapy after resection for lung cancer. Ann Thorac Surg. 2007 Apr;83(4):1245–1249.
Journal cover image

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

April 2007

Volume

83

Issue

4

Start / End Page

1245 / 1249

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Thoracotomy
  • Thoracoscopy
  • Survival Analysis
  • Statistics, Nonparametric
  • Risk Assessment
  • Retrospective Studies
  • Respiratory System
  • Prognosis
  • Probability