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Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes.

Publication ,  Journal Article
Chu, VH; Crosslin, DR; Friedman, JY; Reed, SD; Cabell, CH; Griffiths, RI; Masselink, LE; Kaye, KS; Corey, GR; Reller, LB; Stryjewski, ME ...
Published in: Am J Med
December 2005

PURPOSE: Although Staphylococcus aureus is a leading cause of nosocomial infection, little is known about the impact of S. aureus bacteremia on patients with prosthetic devices. This investigation sought to define the clinical outcome, health care resource use, and infection-associated costs of S. aureus bacteremia in patients with prostheses. SUBJECTS AND METHODS: All hospitalized patients with a prosthetic device and S. aureus bacteremia during the 96-month study period were identified prospectively. Clinical data were collected at the time of hospitalization. Data regarding infection-related resource utilization and infection-related costs within 12 weeks of the initial bacteremia were also recorded. RESULTS: 298 patients with > or =1 prosthesis and S. aureus bacteremia were identified (cardiovascular device--122 patients, orthopedic device--73 patients, long-term catheter--71 patients, and other devices-32 patients). Overall, 58% of patients underwent surgery as a consequence of the infection. Infection-related complications occurred in 41% and the overall 12-week mortality was 27%. The mean infection-related cost was 67439 dollars for patients with hospital-acquired S. aureus bacteremia and 37868 dollars for community-acquired S. aureus bacteremia (cost difference 29571 dollars; 95% confidence interval, 14370 dollars-49826 dollars). Rates of device infection, complications, 12-week mortality, and mean cost varied by prosthesis type. CONCLUSION: S. aureus bacteremia in patients with prosthetic devices is associated with frequent complications, substantial cost, and significant health care resource utilization.

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Published In

Am J Med

DOI

EISSN

1555-7162

Publication Date

December 2005

Volume

118

Issue

12

Start / End Page

1416

Location

United States

Related Subject Headings

  • Staphylococcus aureus
  • Staphylococcal Infections
  • Retrospective Studies
  • Prostheses and Implants
  • Outcome Assessment, Health Care
  • Middle Aged
  • Male
  • Inpatients
  • Humans
  • Health Services
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chu, V. H., Crosslin, D. R., Friedman, J. Y., Reed, S. D., Cabell, C. H., Griffiths, R. I., … Fowler, V. G. (2005). Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes. Am J Med, 118(12), 1416. https://doi.org/10.1016/j.amjmed.2005.06.011
Chu, Vivian H., David R. Crosslin, Joelle Y. Friedman, Shelby D. Reed, Christopher H. Cabell, Robert I. Griffiths, Leah E. Masselink, et al. “Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes.Am J Med 118, no. 12 (December 2005): 1416. https://doi.org/10.1016/j.amjmed.2005.06.011.
Chu VH, Crosslin DR, Friedman JY, Reed SD, Cabell CH, Griffiths RI, et al. Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes. Am J Med. 2005 Dec;118(12):1416.
Chu, Vivian H., et al. “Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes.Am J Med, vol. 118, no. 12, Dec. 2005, p. 1416. Pubmed, doi:10.1016/j.amjmed.2005.06.011.
Chu VH, Crosslin DR, Friedman JY, Reed SD, Cabell CH, Griffiths RI, Masselink LE, Kaye KS, Corey GR, Reller LB, Stryjewski ME, Schulman KA, Fowler VG. Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes. Am J Med. 2005 Dec;118(12):1416.
Journal cover image

Published In

Am J Med

DOI

EISSN

1555-7162

Publication Date

December 2005

Volume

118

Issue

12

Start / End Page

1416

Location

United States

Related Subject Headings

  • Staphylococcus aureus
  • Staphylococcal Infections
  • Retrospective Studies
  • Prostheses and Implants
  • Outcome Assessment, Health Care
  • Middle Aged
  • Male
  • Inpatients
  • Humans
  • Health Services