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Staphylococcus aureus endocarditis: a consequence of medical progress.

Publication ,  Journal Article
Fowler, VG; Miro, JM; Hoen, B; Cabell, CH; Abrutyn, E; Rubinstein, E; Corey, GR; Spelman, D; Bradley, SF; Barsic, B; Pappas, PA; Anstrom, KJ ...
Published in: JAMA
June 22, 2005

CONTEXT: The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown. OBJECTIVES: To document the international emergence of health care-associated S aureus IE and methicillin-resistant S aureus (MRSA) IE and to evaluate regional variation in patients with S aureus IE. DESIGN, SETTING, AND PARTICIPANTS: Prospective observational cohort study set in 39 medical centers in 16 countries. Participants were a population of 1779 patients with definite IE as defined by Duke criteria who were enrolled in the International Collaboration on Endocarditis-Prospective Cohort Study from June 2000 to December 2003. MAIN OUTCOME MEASURE: In-hospital mortality. RESULTS: S aureus was the most common pathogen among the 1779 cases of definite IE in the International Collaboration on Endocarditis Prospective-Cohort Study (558 patients, 31.4%). Health care-associated infection was the most common form of S aureus IE (218 patients, 39.1%), accounting for 25.9% (Australia/New Zealand) to 54.2% (Brazil) of cases. Most patients with health care-associated S aureus IE (131 patients, 60.1%) acquired the infection outside of the hospital. MRSA IE was more common in the United States (37.2%) and Brazil (37.5%) than in Europe/Middle East (23.7%) and Australia/New Zealand (15.5%, P<.001). Persistent bacteremia was independently associated with MRSA IE (odds ratio, 6.2; 95% confidence interval, 2.9-13.2). Patients in the United States were most likely to be hemodialysis dependent, to have diabetes, to have a presumed intravascular device source, to receive vancomycin, to be infected with MRSA, and to have persistent bacteremia (P<.001 for all comparisons). CONCLUSIONS: S aureus is the leading cause of IE in many regions of the world. Characteristics of patients with S aureus IE vary significantly by region. Further studies are required to determine the causes of regional variation.

Duke Scholars

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Published In

JAMA

DOI

EISSN

1538-3598

Publication Date

June 22, 2005

Volume

293

Issue

24

Start / End Page

3012 / 3021

Location

United States

Related Subject Headings

  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prospective Studies
  • Methicillin Resistance
  • Humans
  • Hospital Mortality
  • Global Health
  • General & Internal Medicine
  • Endocarditis, Bacterial
  • Cross Infection
 

Citation

APA
Chicago
ICMJE
MLA
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Fowler, V. G., Miro, J. M., Hoen, B., Cabell, C. H., Abrutyn, E., Rubinstein, E., … ICE Investigators, . (2005). Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA, 293(24), 3012–3021. https://doi.org/10.1001/jama.293.24.3012
Fowler, Vance G., Jose M. Miro, Bruno Hoen, Christopher H. Cabell, Elias Abrutyn, Ethan Rubinstein, G Ralph Corey, et al. “Staphylococcus aureus endocarditis: a consequence of medical progress.JAMA 293, no. 24 (June 22, 2005): 3012–21. https://doi.org/10.1001/jama.293.24.3012.
Fowler VG, Miro JM, Hoen B, Cabell CH, Abrutyn E, Rubinstein E, et al. Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA. 2005 Jun 22;293(24):3012–21.
Fowler, Vance G., et al. “Staphylococcus aureus endocarditis: a consequence of medical progress.JAMA, vol. 293, no. 24, June 2005, pp. 3012–21. Pubmed, doi:10.1001/jama.293.24.3012.
Fowler VG, Miro JM, Hoen B, Cabell CH, Abrutyn E, Rubinstein E, Corey GR, Spelman D, Bradley SF, Barsic B, Pappas PA, Anstrom KJ, Wray D, Fortes CQ, Anguera I, Athan E, Jones P, van der Meer JTM, Elliott TSJ, Levine DP, Bayer AS, ICE Investigators. Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA. 2005 Jun 22;293(24):3012–3021.
Journal cover image

Published In

JAMA

DOI

EISSN

1538-3598

Publication Date

June 22, 2005

Volume

293

Issue

24

Start / End Page

3012 / 3021

Location

United States

Related Subject Headings

  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prospective Studies
  • Methicillin Resistance
  • Humans
  • Hospital Mortality
  • Global Health
  • General & Internal Medicine
  • Endocarditis, Bacterial
  • Cross Infection