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Failure of amphotericin B colloidal dispersion in the treatment of paracoccidioidomycosis.

Publication ,  Journal Article
Dietze, R; Fowler, VG; Steiner, TS; Pecanha, PM; Corey, GR
Published in: Am J Trop Med Hyg
May 1999

Although amphotericin B desoxycholate is considered the most effective treatment for disseminated Paracoccidioides brasiliensis infections, little is known about the efficacy of lipid-based formulations of amphotericin B in this infection. In this study, we treated four adults with the juvenile form of paracoccidioidomycosis with 3 mg/kg/day of amphotericin B colloidal dispersion for at least 28 days. Although all of the patients initially responded by clinical observation, all four patients relapsed within six months. The use of amphotericin B colloidal dispersion for the initial induction of paracoccidioidomycosis failed to cure this infection. Possible reasons for failure include dose, duration, or reduced efficacy of this lipid preparation. For many fungal infections, lipid-based preparations have been shown to have a therapeutic-toxic advantage, but our experience with Paracoccidioides infections suggests that more careful studies will need to be performed before they can be recommended for use in this mycosis.

Duke Scholars

Published In

Am J Trop Med Hyg

DOI

ISSN

0002-9637

Publication Date

May 1999

Volume

60

Issue

5

Start / End Page

837 / 839

Location

United States

Related Subject Headings

  • Tropical Medicine
  • Treatment Failure
  • Paracoccidioidomycosis
  • Paracoccidioides
  • Humans
  • Colloids
  • Antifungal Agents
  • Amphotericin B
  • Adult
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Dietze, R., Fowler, V. G., Steiner, T. S., Pecanha, P. M., & Corey, G. R. (1999). Failure of amphotericin B colloidal dispersion in the treatment of paracoccidioidomycosis. Am J Trop Med Hyg, 60(5), 837–839. https://doi.org/10.4269/ajtmh.1999.60.837
Dietze, R., V. G. Fowler, T. S. Steiner, P. M. Pecanha, and G. R. Corey. “Failure of amphotericin B colloidal dispersion in the treatment of paracoccidioidomycosis.Am J Trop Med Hyg 60, no. 5 (May 1999): 837–39. https://doi.org/10.4269/ajtmh.1999.60.837.
Dietze R, Fowler VG, Steiner TS, Pecanha PM, Corey GR. Failure of amphotericin B colloidal dispersion in the treatment of paracoccidioidomycosis. Am J Trop Med Hyg. 1999 May;60(5):837–9.
Dietze, R., et al. “Failure of amphotericin B colloidal dispersion in the treatment of paracoccidioidomycosis.Am J Trop Med Hyg, vol. 60, no. 5, May 1999, pp. 837–39. Pubmed, doi:10.4269/ajtmh.1999.60.837.
Dietze R, Fowler VG, Steiner TS, Pecanha PM, Corey GR. Failure of amphotericin B colloidal dispersion in the treatment of paracoccidioidomycosis. Am J Trop Med Hyg. 1999 May;60(5):837–839.

Published In

Am J Trop Med Hyg

DOI

ISSN

0002-9637

Publication Date

May 1999

Volume

60

Issue

5

Start / End Page

837 / 839

Location

United States

Related Subject Headings

  • Tropical Medicine
  • Treatment Failure
  • Paracoccidioidomycosis
  • Paracoccidioides
  • Humans
  • Colloids
  • Antifungal Agents
  • Amphotericin B
  • Adult
  • 42 Health sciences