Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus.
Publication
, Journal Article
Nannini, EC; Stryjewski, ME; Singh, KV; Rude, TH; Corey, GR; Fowler, VG; Murray, BE
Published in: Antimicrob Agents Chemother
May 2010
Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime. Ceftobiprole showed the lowest MICs at a high inoculum but with a slight increase for Bla-positive versus Bla-negative strains. Since a potential therapeutic effect associated with a cephalosporin inoculum effect has been described, further studies are warranted.
Duke Scholars
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
May 2010
Volume
54
Issue
5
Start / End Page
2206 / 2208
Location
United States
Related Subject Headings
- Staphylococcus aureus
- Staphylococcal Infections
- Microbiology
- Microbial Sensitivity Tests
- Methicillin
- Humans
- Cephalothin
- Cephalosporins
- Cephalexin
- Cefuroxime
Citation
APA
Chicago
ICMJE
MLA
NLM
Nannini, E. C., Stryjewski, M. E., Singh, K. V., Rude, T. H., Corey, G. R., Fowler, V. G., & Murray, B. E. (2010). Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus. Antimicrob Agents Chemother, 54(5), 2206–2208. https://doi.org/10.1128/AAC.01325-09
Nannini, Esteban C., Martin E. Stryjewski, Kavindra V. Singh, Tom H. Rude, G Ralph Corey, Vance G. Fowler, and Barbara E. Murray. “Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus.” Antimicrob Agents Chemother 54, no. 5 (May 2010): 2206–8. https://doi.org/10.1128/AAC.01325-09.
Nannini EC, Stryjewski ME, Singh KV, Rude TH, Corey GR, Fowler VG, et al. Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2010 May;54(5):2206–8.
Nannini, Esteban C., et al. “Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus.” Antimicrob Agents Chemother, vol. 54, no. 5, May 2010, pp. 2206–08. Pubmed, doi:10.1128/AAC.01325-09.
Nannini EC, Stryjewski ME, Singh KV, Rude TH, Corey GR, Fowler VG, Murray BE. Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2010 May;54(5):2206–2208.
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
May 2010
Volume
54
Issue
5
Start / End Page
2206 / 2208
Location
United States
Related Subject Headings
- Staphylococcus aureus
- Staphylococcal Infections
- Microbiology
- Microbial Sensitivity Tests
- Methicillin
- Humans
- Cephalothin
- Cephalosporins
- Cephalexin
- Cefuroxime