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Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.

Publication ,  Journal Article
Milano, CA; Allen, LF; Rockman, HA; Dolber, PC; McMinn, TR; Chien, KR; Johnson, TD; Bond, RA; Lefkowitz, RJ
Published in: Science
April 22, 1994

Transgenic mice were created with cardiac-specific overexpression of the beta 2-adrenergic receptor. This resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in the transgenic animals were equal to those observed in control animals maximally stimulated with isoproterenol. These results illustrate a useful approach for studying the effect of gene expression on cardiac contractility. Because chronic heart failure in humans is accompanied by a reduction in the number of myocardial beta-adrenergic receptors and in inotropic responsiveness, these results suggest a potential gene therapy approach to this disease state.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

April 22, 1994

Volume

264

Issue

5158

Start / End Page

582 / 586

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Receptors, Adrenergic, beta
  • Promoter Regions, Genetic
  • Phenotype
  • Myosins
  • Myocardium
  • Myocardial Contraction
  • Mice, Transgenic
  • Mice
  • Isoproterenol
 

Citation

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Milano, C. A., Allen, L. F., Rockman, H. A., Dolber, P. C., McMinn, T. R., Chien, K. R., … Lefkowitz, R. J. (1994). Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science, 264(5158), 582–586. https://doi.org/10.1126/science.8160017
Milano, C. A., L. F. Allen, H. A. Rockman, P. C. Dolber, T. R. McMinn, K. R. Chien, T. D. Johnson, R. A. Bond, and R. J. Lefkowitz. “Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.Science 264, no. 5158 (April 22, 1994): 582–86. https://doi.org/10.1126/science.8160017.
Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, Chien KR, et al. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science. 1994 Apr 22;264(5158):582–6.
Milano, C. A., et al. “Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.Science, vol. 264, no. 5158, Apr. 1994, pp. 582–86. Pubmed, doi:10.1126/science.8160017.
Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, Chien KR, Johnson TD, Bond RA, Lefkowitz RJ. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science. 1994 Apr 22;264(5158):582–586.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

April 22, 1994

Volume

264

Issue

5158

Start / End Page

582 / 586

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Receptors, Adrenergic, beta
  • Promoter Regions, Genetic
  • Phenotype
  • Myosins
  • Myocardium
  • Myocardial Contraction
  • Mice, Transgenic
  • Mice
  • Isoproterenol