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Umbilical cord blood transplantation for non-malignant diseases.

Publication ,  Journal Article
Prasad, VK; Kurtzberg, J
Published in: Bone Marrow Transplant
November 2009

Many factors, including lower risk of GVHD, rapid availability of 4/6-6/6 matched cord blood (CB) units and incremental gains in the outcomes, have led to an increasing use of CB transplantation (CBT) to treat many patients who lack fully matched adult BM donors. A large electronically searchable worldwide inventory of publicly banked CB units allows for quicker donor identification and selection. In this review, we examine the current status and cumulative experience of related and unrelated donor CBT for the treatment of non-malignant diseases, including hemoglobinopathies, BM failure syndromes, primary immunodeficiency diseases (PIDs) and inherited metabolic disorders (IMDs), and conclude that CBT offers a promising and effective therapy for these diseases. Future strategies to facilitate earlier diagnosis and to decrease transplant-related risks should further improve the short- and long-term outcomes. Every effort should be made to perform transplantation early in the course of disease before extensive damage to various tissues and organs ensues.

Duke Scholars

Published In

Bone Marrow Transplant

DOI

EISSN

1476-5365

Publication Date

November 2009

Volume

44

Issue

10

Start / End Page

643 / 651

Location

England

Related Subject Headings

  • Metabolism, Inborn Errors
  • Immunology
  • Immunologic Deficiency Syndromes
  • Humans
  • Hemoglobinopathies
  • Graft Rejection
  • Cord Blood Stem Cell Transplantation
  • Clinical Trials as Topic
  • Animals
  • 3211 Oncology and carcinogenesis
 

Citation

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Prasad, V. K., & Kurtzberg, J. (2009). Umbilical cord blood transplantation for non-malignant diseases. Bone Marrow Transplant, 44(10), 643–651. https://doi.org/10.1038/bmt.2009.290
Prasad, V. K., and J. Kurtzberg. “Umbilical cord blood transplantation for non-malignant diseases.Bone Marrow Transplant 44, no. 10 (November 2009): 643–51. https://doi.org/10.1038/bmt.2009.290.
Prasad VK, Kurtzberg J. Umbilical cord blood transplantation for non-malignant diseases. Bone Marrow Transplant. 2009 Nov;44(10):643–51.
Prasad, V. K., and J. Kurtzberg. “Umbilical cord blood transplantation for non-malignant diseases.Bone Marrow Transplant, vol. 44, no. 10, Nov. 2009, pp. 643–51. Pubmed, doi:10.1038/bmt.2009.290.
Prasad VK, Kurtzberg J. Umbilical cord blood transplantation for non-malignant diseases. Bone Marrow Transplant. 2009 Nov;44(10):643–651.

Published In

Bone Marrow Transplant

DOI

EISSN

1476-5365

Publication Date

November 2009

Volume

44

Issue

10

Start / End Page

643 / 651

Location

England

Related Subject Headings

  • Metabolism, Inborn Errors
  • Immunology
  • Immunologic Deficiency Syndromes
  • Humans
  • Hemoglobinopathies
  • Graft Rejection
  • Cord Blood Stem Cell Transplantation
  • Clinical Trials as Topic
  • Animals
  • 3211 Oncology and carcinogenesis