Skip to main content
Journal cover image

A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice.

Publication ,  Journal Article
Tillmann, HL; Thompson, AJ; Patel, K; Wiese, M; Tenckhoff, H; Nischalke, HD; Lokhnygina, Y; Kullig, U; Göbel, U; Capka, E; Wiegand, J; Timm, J ...
Published in: Gastroenterology
November 2010

BACKGROUND & AIMS: A single nucleotide polymorphism (SNP) upstream of the IL28B gene has been associated with response of patients with chronic hepatitis C to therapy with pegylated interferon and ribavirin and also with spontaneous clearance of acute hepatitis C in a heterogeneous population. We analyzed the association between IL28B and the clinical presentation of acute hepatitis C virus (HCV) infection in a homogeneous population. METHODS: We analyzed the SNP rs12979860 in 190 women from the German anti-D cohort (infected with HCV genotype 1b via contaminated rhesus prophylaxis) and its association with spontaneous clearance. Clinical data were available in 136 women with acute infection who were also evaluated for IL28B genotype. Based on results of a TaqMan polymerase chain reaction assay, the rs12979860 SNP genotypes studied were C/C, C/T, or T/T. RESULTS: Spontaneous clearance was more common in patients with the C/C genotype (43/67; 64%) compared with C/T (22/90; 24%) or T/T (2/33; 6%) (P < .001). Jaundice during acute infection was more common among patients with C/C genotype (32.7%) than non-C/C patients (with C/T or T/T) (16.1%; P = .032). In C/C patients, jaundice during acute infection was not associated with an increased chance of spontaneous clearance (56.3%) compared with those without jaundice (60.6%). In contrast, in non-C/C patients, jaundice was associated with a higher likelihood of spontaneous clearance (42.9%) compared with those without jaundice (13.7%). CONCLUSIONS: The SNP rs12979860 upstream of IL28B is associated with spontaneous clearance of HCV. Women with the C/T or T/T genotype who did not develop jaundice had a lower chance of spontaneous clearance of HCV infection.

Duke Scholars

Published In

Gastroenterology

DOI

EISSN

1528-0012

Publication Date

November 2010

Volume

139

Issue

5

Start / End Page

1586 / 1592.e1

Location

United States

Related Subject Headings

  • Young Adult
  • Time Factors
  • Retrospective Studies
  • Prognosis
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Jaundice
  • Interleukins
  • Interferons
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tillmann, H. L., Thompson, A. J., Patel, K., Wiese, M., Tenckhoff, H., Nischalke, H. D., … German Anti-D Study Group, . (2010). A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology, 139(5), 1586-1592.e1. https://doi.org/10.1053/j.gastro.2010.07.005
Tillmann, Hans L., Alex J. Thompson, Keyur Patel, Manfred Wiese, Hannelore Tenckhoff, Hans D. Nischalke, Yuliya Lokhnygina, et al. “A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice.Gastroenterology 139, no. 5 (November 2010): 1586-1592.e1. https://doi.org/10.1053/j.gastro.2010.07.005.
Tillmann HL, Thompson AJ, Patel K, Wiese M, Tenckhoff H, Nischalke HD, et al. A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology. 2010 Nov;139(5):1586-1592.e1.
Tillmann, Hans L., et al. “A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice.Gastroenterology, vol. 139, no. 5, Nov. 2010, pp. 1586-1592.e1. Pubmed, doi:10.1053/j.gastro.2010.07.005.
Tillmann HL, Thompson AJ, Patel K, Wiese M, Tenckhoff H, Nischalke HD, Lokhnygina Y, Kullig U, Göbel U, Capka E, Wiegand J, Schiefke I, Güthoff W, Grüngreiff K, König I, Spengler U, McCarthy J, Shianna KV, Goldstein DB, McHutchison JG, Timm J, Nattermann J, German Anti-D Study Group. A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology. 2010 Nov;139(5):1586-1592.e1.
Journal cover image

Published In

Gastroenterology

DOI

EISSN

1528-0012

Publication Date

November 2010

Volume

139

Issue

5

Start / End Page

1586 / 1592.e1

Location

United States

Related Subject Headings

  • Young Adult
  • Time Factors
  • Retrospective Studies
  • Prognosis
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Jaundice
  • Interleukins
  • Interferons
  • Humans