Skip to main content

Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.

Publication ,  Journal Article
Kelemen, LE; Goodman, MT; McGuire, V; Rossing, MA; Webb, PM; Australian Cancer Study (Ovarian Cancer) Study Group, ; Köbel, M; Anton-Culver, H ...
Published in: Cancer Epidemiol Biomarkers Prev
July 2010

BACKGROUND: We previously reported the risks of ovarian carcinoma for common polymorphisms in one-carbon transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990, and TYMS rs495139 with risk of ovarian carcinoma overall and to use the large sample of assembled cases to investigate associations by histologic type. METHODS: Associations were evaluated in the Ovarian Cancer Association Consortium, including 16 studies of 5,593 epithelial ovarian carcinoma cases and 9,962 controls of white non-Hispanic origin. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for age and study site. RESULTS: The five polymorphisms were not associated with ovarian carcinoma overall (P(trend) > 0.13); however, associations for the minor allele at TYMS rs495139 were observed for carcinomas of mucinous type (OR, 1.19; 95% CI, 1.03-1.39; P = 0.02), clear cell type (OR, 0.86; 95% CI, 0.75-0.99; P = 0.04), and endometrioid type (OR, 0.90; 95% CI, 0.81-0.99; P = 0.04; P(heterogeneity) = 0.001). Restriction to low-grade mucinous carcinomas further strengthened the association for the mucinous type (OR, 1.32; 95% CI, 1.07-1.62; P = 0.01). TYMS rs495139 was not associated with serous type (OR, 1.06; 95% CI, 1.00-1.13; P = 0.05). CONCLUSIONS: TYMS rs495139 may be associated with a differential risk of ovarian carcinoma types, indicating the importance of accurate histopathologic classification. IMPACT: Biomarkers that distinguish ovarian carcinoma types are few, and TYMS rs495139 may provide a novel clue to type etiology.

Duke Scholars

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

July 2010

Volume

19

Issue

7

Start / End Page

1822 / 1830

Location

United States

Related Subject Headings

  • Thymidylate Synthase
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Minor Histocompatibility Antigens
  • Middle Aged
  • Methylenetetrahydrofolate Dehydrogenase (NADP)
  • Humans
  • Genotype
  • Genetic Variation
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kelemen, L. E., Goodman, M. T., McGuire, V., Rossing, M. A., Webb, P. M., Australian Cancer Study (Ovarian Cancer) Study Group, ., … Ovarian Cancer Association Consortium, . (2010). Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev, 19(7), 1822–1830. https://doi.org/10.1158/1055-9965.EPI-09-1317
Kelemen, Linda E., Marc T. Goodman, Valerie McGuire, Mary Anne Rossing, Penelope M. Webb, Penelope M. Australian Cancer Study (Ovarian Cancer) Study Group, Martin Köbel, et al. “Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.Cancer Epidemiol Biomarkers Prev 19, no. 7 (July 2010): 1822–30. https://doi.org/10.1158/1055-9965.EPI-09-1317.
Kelemen LE, Goodman MT, McGuire V, Rossing MA, Webb PM, Australian Cancer Study (Ovarian Cancer) Study Group, et al. Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev. 2010 Jul;19(7):1822–30.
Kelemen, Linda E., et al. “Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.Cancer Epidemiol Biomarkers Prev, vol. 19, no. 7, July 2010, pp. 1822–30. Pubmed, doi:10.1158/1055-9965.EPI-09-1317.
Kelemen LE, Goodman MT, McGuire V, Rossing MA, Webb PM, Australian Cancer Study (Ovarian Cancer) Study Group, Köbel M, Anton-Culver H, Beesley J, Berchuck A, Brar S, Carney ME, Chang-Claude J, Chenevix-Trench G, Australian Ovarian Cancer Study Group, Cramer DW, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Fredericksen ZS, Fridley BL, Gates MA, Gayther SA, Gentry-Maharaj A, Høgdall E, Kjaer SK, Lurie G, Menon U, Moorman PG, Moysich K, Ness RB, Palmieri RT, Pearce CL, Pharoah PDP, Ramus SJ, Song H, Stram DO, Tworoger SS, Van Den Berg D, Vierkant RA, Wang-Gohrke S, Whittemore AS, Wilkens LR, Wu AH, Schildkraut JM, Sellers TA, Goode EL, Ovarian Cancer Association Consortium. Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev. 2010 Jul;19(7):1822–1830.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

July 2010

Volume

19

Issue

7

Start / End Page

1822 / 1830

Location

United States

Related Subject Headings

  • Thymidylate Synthase
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Minor Histocompatibility Antigens
  • Middle Aged
  • Methylenetetrahydrofolate Dehydrogenase (NADP)
  • Humans
  • Genotype
  • Genetic Variation
  • Genetic Predisposition to Disease