Skip to main content
Journal cover image

Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis.

Publication ,  Journal Article
Moorman, PG; Iversen, ES; Marcom, PK; Marks, JR; Wang, F; Kathleen Cuningham Consortium for Research into Familial Breast Cancer, ; Lee, E ...
Published in: Breast Cancer Res Treat
November 2010

The incomplete penetrance of mutations in BRCA1 and BRCA2 suggests that some combination of environmental and genetic factors modifies the risk of breast cancer in mutation carriers. This study sought to identify possible interactions between established breast cancer risk factors and BRCA1 or BRCA2 mutations using a case-only study design. Breast cancer cases that had been tested for BRCA1 and BRCA2 mutations were identified from 11 collaborating centers. Comparisons of reproductive and lifestyle risk factors were made between women with breast cancer who were positive for BRCA1 mutations (n = 283), BRCA2 mutations (n = 204), or negative for both BRCA1 and BRCA2 mutations (n = 894). Interaction risk ratios (IRRs) were calculated using multinominal logistic regression models. Compared with non-carriers, statistically significant IRRs were observed for later age at menarche among BRCA2 mutation carriers, for a greater number of pregnancies among both BRCA1 and BRCA2 mutation carriers, and for alcohol use among BRCA1 mutation carriers. Our data suggest that the risk for breast cancer among BRCA1 or BRCA2 carriers may be modified by reproductive characteristics and alcohol use. However, our results should be interpreted cautiously given the overall inconsistency in the epidemiologic literature on modifiers of BRCA1 and BRCA2.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

November 2010

Volume

124

Issue

2

Start / End Page

441 / 451

Location

Netherlands

Related Subject Headings

  • Young Adult
  • United States
  • Risk Factors
  • Risk Assessment
  • Pregnancy
  • Phenotype
  • Parity
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Mutation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Moorman, P. G., Iversen, E. S., Marcom, P. K., Marks, J. R., Wang, F., Kathleen Cuningham Consortium for Research into Familial Breast Cancer, ., … Schildkraut, J. M. (2010). Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis. Breast Cancer Res Treat, 124(2), 441–451. https://doi.org/10.1007/s10549-010-0842-y
Moorman, Patricia G., Edwin S. Iversen, P Kelly Marcom, Jeffrey R. Marks, Frances Wang, Frances Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Eunjung Lee, et al. “Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis.Breast Cancer Res Treat 124, no. 2 (November 2010): 441–51. https://doi.org/10.1007/s10549-010-0842-y.
Moorman PG, Iversen ES, Marcom PK, Marks JR, Wang F, Kathleen Cuningham Consortium for Research into Familial Breast Cancer, et al. Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis. Breast Cancer Res Treat. 2010 Nov;124(2):441–51.
Moorman, Patricia G., et al. “Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis.Breast Cancer Res Treat, vol. 124, no. 2, Nov. 2010, pp. 441–51. Pubmed, doi:10.1007/s10549-010-0842-y.
Moorman PG, Iversen ES, Marcom PK, Marks JR, Wang F, Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Lee E, Ursin G, Rebbeck TR, Domchek SM, Arun B, Susswein L, Isaacs C, Garber JE, Visvanathan K, Griffin CA, Sutphen R, Brzosowicz J, Gruber S, Finkelstein DM, Schildkraut JM. Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis. Breast Cancer Res Treat. 2010 Nov;124(2):441–451.
Journal cover image

Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

November 2010

Volume

124

Issue

2

Start / End Page

441 / 451

Location

Netherlands

Related Subject Headings

  • Young Adult
  • United States
  • Risk Factors
  • Risk Assessment
  • Pregnancy
  • Phenotype
  • Parity
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Mutation