Oncolytic viruses for cancer therapy II. Cell-internal factors for conditional growth in neoplastic cells.
Publication
, Journal Article
Campbell, SA; Gromeier, M
Published in: Onkologie
April 2005
Recent advances in our understanding of virus-host interactions have fueled new studies in the field of oncolytic viruses. The first part of this review explained how cell-external factors, such as cellular receptors, influence tumor tropism and specificity of oncolytic virus candidates. In the second part of this review, we focus on cellinternal factors that mediate tumor-specific virus growth. An oncolytic virus must be able to replicate within cancerous cells and kill them without collateral damage to healthy surrounding cells. This desirable property is inherent to some proposed oncolytic viral agents or has been achieved by genetic manipulation in others.
Duke Scholars
Published In
Onkologie
DOI
ISSN
0378-584X
Publication Date
April 2005
Volume
28
Issue
4
Start / End Page
209 / 215
Location
Switzerland
Related Subject Headings
- Viruses
- Virus Replication
- Receptors, Virus
- Oncology & Carcinogenesis
- Neoplasms
- Humans
- Genetic Vectors
- Genetic Therapy
- Genetic Engineering
- Gene Deletion
Citation
APA
Chicago
ICMJE
MLA
NLM
Campbell, S. A., & Gromeier, M. (2005). Oncolytic viruses for cancer therapy II. Cell-internal factors for conditional growth in neoplastic cells. Onkologie, 28(4), 209–215. https://doi.org/10.1159/000084010
Campbell, Stephanie A., and Matthias Gromeier. “Oncolytic viruses for cancer therapy II. Cell-internal factors for conditional growth in neoplastic cells.” Onkologie 28, no. 4 (April 2005): 209–15. https://doi.org/10.1159/000084010.
Campbell SA, Gromeier M. Oncolytic viruses for cancer therapy II. Cell-internal factors for conditional growth in neoplastic cells. Onkologie. 2005 Apr;28(4):209–15.
Campbell, Stephanie A., and Matthias Gromeier. “Oncolytic viruses for cancer therapy II. Cell-internal factors for conditional growth in neoplastic cells.” Onkologie, vol. 28, no. 4, Apr. 2005, pp. 209–15. Pubmed, doi:10.1159/000084010.
Campbell SA, Gromeier M. Oncolytic viruses for cancer therapy II. Cell-internal factors for conditional growth in neoplastic cells. Onkologie. 2005 Apr;28(4):209–215.
Published In
Onkologie
DOI
ISSN
0378-584X
Publication Date
April 2005
Volume
28
Issue
4
Start / End Page
209 / 215
Location
Switzerland
Related Subject Headings
- Viruses
- Virus Replication
- Receptors, Virus
- Oncology & Carcinogenesis
- Neoplasms
- Humans
- Genetic Vectors
- Genetic Therapy
- Genetic Engineering
- Gene Deletion