Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites.
Publication
, Journal Article
Dufresne, AT; Dobrikova, EY; Schmidt, S; Gromeier, M
Published in: J Virol
September 2002
In many respects, picornaviruses are well suited for their proposed use as immunization vectors. However, their inherent genetic instability hinders application for prophylactic purposes. We demonstrate the improved expression and stability of a heterologous insert through a novel vector design strategy that partially replaces noncoding regulatory sequences with coding sequences for foreign gene products.
Duke Scholars
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Published In
J Virol
DOI
ISSN
0022-538X
Publication Date
September 2002
Volume
76
Issue
17
Start / End Page
8966 / 8972
Location
United States
Related Subject Headings
- Virology
- Viral Matrix Proteins
- Simian immunodeficiency virus
- Simian Immunodeficiency Virus
- Ribosomes
- Rhinovirus
- Recombination, Genetic
- Picornaviridae
- Molecular Sequence Data
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Dufresne, A. T., Dobrikova, E. Y., Schmidt, S., & Gromeier, M. (2002). Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites. J Virol, 76(17), 8966–8972. https://doi.org/10.1128/jvi.76.17.8966-8972.2002
Dufresne, Andrew T., Elena Y. Dobrikova, Stacie Schmidt, and Matthias Gromeier. “Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites.” J Virol 76, no. 17 (September 2002): 8966–72. https://doi.org/10.1128/jvi.76.17.8966-8972.2002.
Dufresne AT, Dobrikova EY, Schmidt S, Gromeier M. Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites. J Virol. 2002 Sep;76(17):8966–72.
Dufresne, Andrew T., et al. “Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites.” J Virol, vol. 76, no. 17, Sept. 2002, pp. 8966–72. Pubmed, doi:10.1128/jvi.76.17.8966-8972.2002.
Dufresne AT, Dobrikova EY, Schmidt S, Gromeier M. Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites. J Virol. 2002 Sep;76(17):8966–8972.
Published In
J Virol
DOI
ISSN
0022-538X
Publication Date
September 2002
Volume
76
Issue
17
Start / End Page
8966 / 8972
Location
United States
Related Subject Headings
- Virology
- Viral Matrix Proteins
- Simian immunodeficiency virus
- Simian Immunodeficiency Virus
- Ribosomes
- Rhinovirus
- Recombination, Genetic
- Picornaviridae
- Molecular Sequence Data
- Humans