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Analysis of primary CD30+ cutaneous lymphoproliferative disease and survival from the Surveillance, Epidemiology, and End Results database.

Publication ,  Journal Article
Yu, JB; Blitzblau, RC; Decker, RH; Housman, DM; Wilson, LD
Published in: J Clin Oncol
March 20, 2008

PURPOSE: Primary CD30+ cutaneous lymphoproliferative disease (PCLPD) is a spectrum of indolent cutaneous T-cell lymphomas. The primary intention of the analysis of the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database was to report epidemiologic information and overall survival of patients with PCLPD. METHODS: We investigated the SEER database from 1973 to 2004 and performed univariable and multivariable survival analysis. RESULTS: A total of 268 cases of PCLPD were recorded from 1973 to 2004. Median age at diagnosis was 61 years (range, 5 to 98 years). Among cases, 58% were male, and 42% female. Race distribution was 87% white, 7% black, and 4% Asian/Pacific Islander. A total of 157 patients had primary, localized PCLPD. For the total population (N = 268), overall survival at 3 years was 81% (95% CI, 74% to 87%). Population-matched relative survival at 3 years was 87% (SE, 3.6%). Disease-specific survival at 5 years was 92% (95% CI, 86% to 95%). Head and neck skin site predicted for inferior overall survival in patients with primary, localized PCLPD on univariable analysis (hazard ratio [HR] = 4.4; P = .008; 95% CI, 1.5 to 13.2), and was suggestive of decreased overall survival on multivariate analysis (HR = 3.0; P = .06; 95% CI, 0.95 to 9.7). CONCLUSION: Localized PCLPDs are rare diseases with an excellent overall survival and occur more frequently in whites and in men. Head and neck skin primary site may be associated with poorer survival. CONCLUSIONS regarding subsets demonstrating association with survival should be taken with caution, given the small number of deaths analyzed.

Duke Scholars

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

March 20, 2008

Volume

26

Issue

9

Start / End Page

1483 / 1488

Location

United States

Related Subject Headings

  • White People
  • Survival Rate
  • SEER Program
  • Prognosis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lymphoma, T-Cell, Cutaneous
  • Ki-1 Antigen
  • Kaplan-Meier Estimate
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yu, J. B., Blitzblau, R. C., Decker, R. H., Housman, D. M., & Wilson, L. D. (2008). Analysis of primary CD30+ cutaneous lymphoproliferative disease and survival from the Surveillance, Epidemiology, and End Results database. J Clin Oncol, 26(9), 1483–1488. https://doi.org/10.1200/JCO.2007.14.1374
Yu, James B., Rachel C. Blitzblau, Roy H. Decker, Douglas M. Housman, and Lynn D. Wilson. “Analysis of primary CD30+ cutaneous lymphoproliferative disease and survival from the Surveillance, Epidemiology, and End Results database.J Clin Oncol 26, no. 9 (March 20, 2008): 1483–88. https://doi.org/10.1200/JCO.2007.14.1374.
Yu JB, Blitzblau RC, Decker RH, Housman DM, Wilson LD. Analysis of primary CD30+ cutaneous lymphoproliferative disease and survival from the Surveillance, Epidemiology, and End Results database. J Clin Oncol. 2008 Mar 20;26(9):1483–8.
Yu, James B., et al. “Analysis of primary CD30+ cutaneous lymphoproliferative disease and survival from the Surveillance, Epidemiology, and End Results database.J Clin Oncol, vol. 26, no. 9, Mar. 2008, pp. 1483–88. Pubmed, doi:10.1200/JCO.2007.14.1374.
Yu JB, Blitzblau RC, Decker RH, Housman DM, Wilson LD. Analysis of primary CD30+ cutaneous lymphoproliferative disease and survival from the Surveillance, Epidemiology, and End Results database. J Clin Oncol. 2008 Mar 20;26(9):1483–1488.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

March 20, 2008

Volume

26

Issue

9

Start / End Page

1483 / 1488

Location

United States

Related Subject Headings

  • White People
  • Survival Rate
  • SEER Program
  • Prognosis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lymphoma, T-Cell, Cutaneous
  • Ki-1 Antigen
  • Kaplan-Meier Estimate