Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism.
Publication
, Journal Article
Gonzalez-Gronow, M; Cuchacovich, M; Francos, R; Cuchacovich, S; Fernandez, MDP; Blanco, A; Bowers, EV; Kaczowka, S; Pizzo, SV
Published in: J Neuroimmunol
October 8, 2010
Autistic children show elevated serum levels of autoantibodies to several proteins essential for the function of normal brains. The voltage-dependent anion channel (VDAC) and hexokinase-I, a VDAC protective ligand, were identified as targets of this autoimmunity in autistic children. These autoantibodies were purified using immunoaffinity chromatographic techniques. Both antibodies induce apoptosis of cultured human neuroblastoma cells. Because VDAC and hexokinase-I are essential for brain protection from ischemic damage, the presence of these autoantibodies suggests a possible causal role in the neurologic pathogenesis of autism.
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Published In
J Neuroimmunol
DOI
EISSN
1872-8421
Publication Date
October 8, 2010
Volume
227
Issue
1-2
Start / End Page
153 / 161
Location
Netherlands
Related Subject Headings
- Voltage-Dependent Anion Channels
- Protein Binding
- Neurology & Neurosurgery
- Neuroimmunomodulation
- Molecular Sequence Data
- Male
- Ligands
- Infant
- Humans
- Hexokinase
Citation
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ICMJE
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Gonzalez-Gronow, M., Cuchacovich, M., Francos, R., Cuchacovich, S., Fernandez, M. D. P., Blanco, A., … Pizzo, S. V. (2010). Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism. J Neuroimmunol, 227(1–2), 153–161. https://doi.org/10.1016/j.jneuroim.2010.06.001
Gonzalez-Gronow, Mario, Miguel Cuchacovich, Rina Francos, Stephanie Cuchacovich, Maria del Pilar Fernandez, Angel Blanco, Edith V. Bowers, Steven Kaczowka, and Salvatore V. Pizzo. “Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism.” J Neuroimmunol 227, no. 1–2 (October 8, 2010): 153–61. https://doi.org/10.1016/j.jneuroim.2010.06.001.
Gonzalez-Gronow M, Cuchacovich M, Francos R, Cuchacovich S, Fernandez MDP, Blanco A, et al. Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism. J Neuroimmunol. 2010 Oct 8;227(1–2):153–61.
Gonzalez-Gronow, Mario, et al. “Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism.” J Neuroimmunol, vol. 227, no. 1–2, Oct. 2010, pp. 153–61. Pubmed, doi:10.1016/j.jneuroim.2010.06.001.
Gonzalez-Gronow M, Cuchacovich M, Francos R, Cuchacovich S, Fernandez MDP, Blanco A, Bowers EV, Kaczowka S, Pizzo SV. Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism. J Neuroimmunol. 2010 Oct 8;227(1–2):153–161.
Published In
J Neuroimmunol
DOI
EISSN
1872-8421
Publication Date
October 8, 2010
Volume
227
Issue
1-2
Start / End Page
153 / 161
Location
Netherlands
Related Subject Headings
- Voltage-Dependent Anion Channels
- Protein Binding
- Neurology & Neurosurgery
- Neuroimmunomodulation
- Molecular Sequence Data
- Male
- Ligands
- Infant
- Humans
- Hexokinase