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Malignant mesothelioma and duration of asbestos exposure: correlation with tissue mineral fibre content.

Publication ,  Journal Article
Roggli, VL
Published in: Ann Occup Hyg
June 1995

Among 441 cases of malignant mesothelioma in the author's files, there were 324 for whom reliable information was available regarding the duration of exposure to asbestos. Included were 298 pleural and 26 peritoneal mesotheliomas. The mean duration of exposure to asbestos was 23 +/- 14 years for all cases, and was not different for the pleural and peritoneal groups. Lung tissue was available for analysis of mineral fibre content in 94 cases. Linear regression analysis showed a significant correlation between duration of exposure and asbestos bodies per gramme of wet lung as determined by light microscopy, and between duration of exposure and total uncoated fibres (5 microns or greater in length) as well as commercial amphibole fibres per gramme as determined by scanning electron microscopy (P < 0.05). Individuals with direct exposures had on average higher asbestos contents than patients with indirect exposures. Furthermore, for each duration of exposure, shipyard workers had on average higher asbestos contents than non-shipyard workers (P < 0.05). Mesotheliomas are associated with a wide range of durations of exposure to asbestos and pulmonary asbestos burdens, and there is a rough correlation between duration of exposure and pulmonary commercial amphibole content.

Duke Scholars

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Published In

Ann Occup Hyg

DOI

ISSN

0003-4878

Publication Date

June 1995

Volume

39

Issue

3

Start / End Page

363 / 374

Location

England

Related Subject Headings

  • Time Factors
  • Occupational Exposure
  • Middle Aged
  • Mesothelioma
  • Male
  • Lung
  • Humans
  • Female
  • Environmental & Occupational Health
  • Asbestos
 

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Roggli, V. L. (1995). Malignant mesothelioma and duration of asbestos exposure: correlation with tissue mineral fibre content. Ann Occup Hyg, 39(3), 363–374. https://doi.org/10.1016/0003-4878(95)00006-z
Roggli, V. L. “Malignant mesothelioma and duration of asbestos exposure: correlation with tissue mineral fibre content.Ann Occup Hyg 39, no. 3 (June 1995): 363–74. https://doi.org/10.1016/0003-4878(95)00006-z.
Roggli, V. L. “Malignant mesothelioma and duration of asbestos exposure: correlation with tissue mineral fibre content.Ann Occup Hyg, vol. 39, no. 3, June 1995, pp. 363–74. Pubmed, doi:10.1016/0003-4878(95)00006-z.
Journal cover image

Published In

Ann Occup Hyg

DOI

ISSN

0003-4878

Publication Date

June 1995

Volume

39

Issue

3

Start / End Page

363 / 374

Location

England

Related Subject Headings

  • Time Factors
  • Occupational Exposure
  • Middle Aged
  • Mesothelioma
  • Male
  • Lung
  • Humans
  • Female
  • Environmental & Occupational Health
  • Asbestos