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Asbestos body concentrations in human lung: predictions from asbestos body counts in tissue sections with a mathematical model.

Publication ,  Journal Article
Vollmer, RT; Roggli, VL
Published in: Hum Pathol
July 1985

A mathematical model for predicting the concentration (Nv) of asbestos bodies (AB) in human tissue from the count (No) of these bodies in planar tissue sections is presented. The result is the equation Nv = No/[0.54 X A X (La + t)], giving the concentration of AB in numbers per gram of wet lung tissue. La, the average length (in microns) of the AB, is specific for each case; A is the area (square millimeters) of the tissue counted, and t is the thickness of the section (in microns). This equation fits experimental digestion results to a multiplicative error factor of less than 3. When an estimate of La, such as 51.6 microns, is used, the equation is less accurate but probably sufficiently accurate for the screening of lung specimens.

Duke Scholars

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

July 1985

Volume

16

Issue

7

Start / End Page

713 / 718

Location

United States

Related Subject Headings

  • Pathology
  • Models, Theoretical
  • Mathematics
  • Lung
  • Iron
  • Humans
  • Asbestos
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Vollmer, R. T., & Roggli, V. L. (1985). Asbestos body concentrations in human lung: predictions from asbestos body counts in tissue sections with a mathematical model. Hum Pathol, 16(7), 713–718. https://doi.org/10.1016/s0046-8177(85)80157-x
Vollmer, R. T., and V. L. Roggli. “Asbestos body concentrations in human lung: predictions from asbestos body counts in tissue sections with a mathematical model.Hum Pathol 16, no. 7 (July 1985): 713–18. https://doi.org/10.1016/s0046-8177(85)80157-x.
Vollmer, R. T., and V. L. Roggli. “Asbestos body concentrations in human lung: predictions from asbestos body counts in tissue sections with a mathematical model.Hum Pathol, vol. 16, no. 7, July 1985, pp. 713–18. Pubmed, doi:10.1016/s0046-8177(85)80157-x.
Journal cover image

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

July 1985

Volume

16

Issue

7

Start / End Page

713 / 718

Location

United States

Related Subject Headings

  • Pathology
  • Models, Theoretical
  • Mathematics
  • Lung
  • Iron
  • Humans
  • Asbestos
  • 3202 Clinical sciences
  • 1103 Clinical Sciences