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Pulmonary blastoma: an ultrastructural and histochemical study.

Publication ,  Journal Article
Jackson, MD; Albrecht, R; Roggli, VL; Shelburne, JD
Published in: Ultrastruct Pathol
1984

We present a unique case of pulmonary blastoma and describe its histology and ultrastructure. The stromal component exhibited bizarre multinucleated giant cells containing previously undescribed granules. These membrane-limited granules were eosinophilic, periodic acid-Schiff positive, diastase resistant, acid phosphatase and nonspecific esterase negative, immunohistologically negative for lysozyme, albumin, and gamma globulin, and often homogeneously electron dense. A similar electron-dense material accumulated in the rough endoplasmic reticulum of these stromal giant cells, suggesting that the material in the granules is synthetic. The material appeared to be a glycoprotein but was not alpha1-antitrypsin, alpha-fetoprotein, or human chorionic gonadotropin by immunohistologic techniques. These stromal cell granules differ from granules described in epithelial cells of other pulmonary blastomas but resemble granules found in some sarcomas.

Duke Scholars

Published In

Ultrastruct Pathol

DOI

ISSN

0191-3123

Publication Date

1984

Volume

7

Issue

4

Start / End Page

259 / 268

Location

England

Related Subject Headings

  • Pathology
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Histocytochemistry
  • Carcinoma, Squamous Cell
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Jackson, M. D., Albrecht, R., Roggli, V. L., & Shelburne, J. D. (1984). Pulmonary blastoma: an ultrastructural and histochemical study. Ultrastruct Pathol, 7(4), 259–268. https://doi.org/10.3109/01913128409141486
Jackson, M. D., R. Albrecht, V. L. Roggli, and J. D. Shelburne. “Pulmonary blastoma: an ultrastructural and histochemical study.Ultrastruct Pathol 7, no. 4 (1984): 259–68. https://doi.org/10.3109/01913128409141486.
Jackson MD, Albrecht R, Roggli VL, Shelburne JD. Pulmonary blastoma: an ultrastructural and histochemical study. Ultrastruct Pathol. 1984;7(4):259–68.
Jackson, M. D., et al. “Pulmonary blastoma: an ultrastructural and histochemical study.Ultrastruct Pathol, vol. 7, no. 4, 1984, pp. 259–68. Pubmed, doi:10.3109/01913128409141486.
Jackson MD, Albrecht R, Roggli VL, Shelburne JD. Pulmonary blastoma: an ultrastructural and histochemical study. Ultrastruct Pathol. 1984;7(4):259–268.
Journal cover image

Published In

Ultrastruct Pathol

DOI

ISSN

0191-3123

Publication Date

1984

Volume

7

Issue

4

Start / End Page

259 / 268

Location

England

Related Subject Headings

  • Pathology
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Histocytochemistry
  • Carcinoma, Squamous Cell
  • 3202 Clinical sciences
  • 1103 Clinical Sciences