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Foregut carcinoids: a clinical and biochemical analysis.

Publication ,  Journal Article
Kirshbom, PM; Kherani, AR; Onaitis, MW; Hata, A; Kehoe, TE; Feldman, C; Feldman, JM; Tyler, DS
Published in: Surgery
December 1999

BACKGROUND: Gastrointestinal foregut carcinoids make up a small percentage (3% to 6%) of all reported carcinoids. Because these tumors are so uncommon, comparisons between the subtypes have been difficult. The goal of this study was to compare the hormonal and clinical characteristics of gastric, duodenal, and pancreatic carcinoids. METHODS: A prospective database of approximately 750 carcinoid patients seen by one author over 25 years was reviewed, and the 104 patients with gastric (33), duodenal (17), or pancreatic (54) carcinoids were selected as the subgroup for analysis. These patients were compared with regard to hormone levels, clinical course, treatment, and survival. RESULTS: Duodenal carcinoids exhibited significantly lower serotoninergic hormone levels than did the gastric and pancreatic carcinoids (urine 5-hydroxyindoleacetic acid [mg/24 h], 5 +/- 1 vs 16 +/- 5 and 47 +/- 12, respectively, P = .03). Pancreatic carcinoids presented with more advanced stage (distant metastases 87% vs 42% and 20% for gastric and duodenal, respectively) and had worse outcomes than patients with gastric and duodenal tumors with 10-year survivals of 10%, 59%, and 58%, respectively (P = .003). CONCLUSIONS: Pancreatic carcinoids produce higher levels of serotoninergic hormones and have a significantly higher stage and worse outcome than other foregut carcinoids. This study demonstrates that the organ of origin is an important determinant of hormonal activity and clinical course for patients with foregut carcinoids.

Duke Scholars

Published In

Surgery

DOI

ISSN

0039-6060

Publication Date

December 1999

Volume

126

Issue

6

Start / End Page

1105 / 1110

Location

United States

Related Subject Headings

  • Survival Analysis
  • Surgery
  • Stomach Neoplasms
  • Sex Distribution
  • Serotonin
  • Retrospective Studies
  • Pancreatic Neoplasms
  • Middle Aged
  • Male
  • Hydroxyindoleacetic Acid
 

Citation

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Kirshbom, P. M., Kherani, A. R., Onaitis, M. W., Hata, A., Kehoe, T. E., Feldman, C., … Tyler, D. S. (1999). Foregut carcinoids: a clinical and biochemical analysis. Surgery, 126(6), 1105–1110. https://doi.org/10.1067/msy.2099.101430
Kirshbom, P. M., A. R. Kherani, M. W. Onaitis, A. Hata, T. E. Kehoe, C. Feldman, J. M. Feldman, and D. S. Tyler. “Foregut carcinoids: a clinical and biochemical analysis.Surgery 126, no. 6 (December 1999): 1105–10. https://doi.org/10.1067/msy.2099.101430.
Kirshbom PM, Kherani AR, Onaitis MW, Hata A, Kehoe TE, Feldman C, et al. Foregut carcinoids: a clinical and biochemical analysis. Surgery. 1999 Dec;126(6):1105–10.
Kirshbom, P. M., et al. “Foregut carcinoids: a clinical and biochemical analysis.Surgery, vol. 126, no. 6, Dec. 1999, pp. 1105–10. Pubmed, doi:10.1067/msy.2099.101430.
Kirshbom PM, Kherani AR, Onaitis MW, Hata A, Kehoe TE, Feldman C, Feldman JM, Tyler DS. Foregut carcinoids: a clinical and biochemical analysis. Surgery. 1999 Dec;126(6):1105–1110.
Journal cover image

Published In

Surgery

DOI

ISSN

0039-6060

Publication Date

December 1999

Volume

126

Issue

6

Start / End Page

1105 / 1110

Location

United States

Related Subject Headings

  • Survival Analysis
  • Surgery
  • Stomach Neoplasms
  • Sex Distribution
  • Serotonin
  • Retrospective Studies
  • Pancreatic Neoplasms
  • Middle Aged
  • Male
  • Hydroxyindoleacetic Acid