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Lambda light chain deposition disease in a renal allograft.

Publication ,  Journal Article
Tanenbaum, ND; Howell, DN; Middleton, JP; Spurney, RF
Published in: Transplant Proc
December 2005

Light chain deposition disease (LCDD) of the kidney is characterized by deposition of monoclonal light chains predominantly in glomeruli and in tubular basement membranes. The disease is frequently associated with a lymphoproliferative disorder, and the majority of cases are caused by deposition of kappa light chains. Although the occurrence of de novo multiple myeloma after renal transplantation is uncommon, there are several reports of LCDD involving renal allografts, either de novo or in patients with a diagnosis of LCDD prior to transplantation. To the best of our knowledge, all previously described cases in allografts have been in patients with kappa chain deposition. The relative importance of intrinsic properties of the kidney in predisposing to either kappa or lambda light chain deposition is not known. We present a case of LCDD caused by deposition of lambda light chains in a patient who received a cadaveric renal transplant.

Duke Scholars

Published In

Transplant Proc

DOI

ISSN

0041-1345

Publication Date

December 2005

Volume

37

Issue

10

Start / End Page

4289 / 4292

Location

United States

Related Subject Headings

  • Renal Circulation
  • Paraproteinemias
  • Male
  • Kidney Tubular Necrosis, Acute
  • Kidney Transplantation
  • Immunoglobulin lambda-Chains
  • Immunoglobulin Light Chains
  • Humans
  • Glomerular Mesangium
  • Coronary Artery Bypass
 

Citation

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Tanenbaum, N. D., Howell, D. N., Middleton, J. P., & Spurney, R. F. (2005). Lambda light chain deposition disease in a renal allograft. Transplant Proc, 37(10), 4289–4292. https://doi.org/10.1016/j.transproceed.2005.10.030
Tanenbaum, N. D., D. N. Howell, J. P. Middleton, and R. F. Spurney. “Lambda light chain deposition disease in a renal allograft.Transplant Proc 37, no. 10 (December 2005): 4289–92. https://doi.org/10.1016/j.transproceed.2005.10.030.
Tanenbaum ND, Howell DN, Middleton JP, Spurney RF. Lambda light chain deposition disease in a renal allograft. Transplant Proc. 2005 Dec;37(10):4289–92.
Tanenbaum, N. D., et al. “Lambda light chain deposition disease in a renal allograft.Transplant Proc, vol. 37, no. 10, Dec. 2005, pp. 4289–92. Pubmed, doi:10.1016/j.transproceed.2005.10.030.
Tanenbaum ND, Howell DN, Middleton JP, Spurney RF. Lambda light chain deposition disease in a renal allograft. Transplant Proc. 2005 Dec;37(10):4289–4292.
Journal cover image

Published In

Transplant Proc

DOI

ISSN

0041-1345

Publication Date

December 2005

Volume

37

Issue

10

Start / End Page

4289 / 4292

Location

United States

Related Subject Headings

  • Renal Circulation
  • Paraproteinemias
  • Male
  • Kidney Tubular Necrosis, Acute
  • Kidney Transplantation
  • Immunoglobulin lambda-Chains
  • Immunoglobulin Light Chains
  • Humans
  • Glomerular Mesangium
  • Coronary Artery Bypass