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CD10 expression in trichoepithelioma and basal cell carcinoma.

Publication ,  Journal Article
Pham, TTN; Selim, MA; Burchette, JL; Madden, J; Turner, J; Herman, C
Published in: J Cutan Pathol
February 2006

BACKGROUND: Trichoepithelioma (TE) is a benign neoplasm that shares both clinical and histologic features with basal cell carcinoma (BCC). However, it is important to distinguish these neoplasms. Limited immunohistochemical stains are available to separate these two tumors. METHODS: CD10 protein immunohistochemistry was performed on paraffin-embedded biopsies of 13 TE and 23 BCC diagnosed by routine microscopy. Cases were analyzed for pattern of CD10 expression by tumor cells and surrounding stroma. RESULTS: Twelve of 13 (92%) TE showed positive stromal immunoreactivity. Of these, eight cases also demonstrated positivity of the papilla, and two also showed positivity of the basaloid cells. No TE demonstrated epithelial expression alone. On the other hand, expression of CD10 by basaloid cells was identified in 20 (87%) cases of BCC. Stromal positivity was also identified in three cases of BCC. Condensation of CD10-positive stromal cells around basaloid nests was statistically significant in differentiating TE from BCC (p < 0.0001). Conversely, CD10-positive basaloid cells were seen predominantly in BCC (p < 0.0001). CONCLUSIONS: This study demonstrates a statistically significant difference in CD10 staining pattern between TE and BCC. Thus, CD10 may be a useful adjunct marker in distinguishing these tumors.

Duke Scholars

Published In

J Cutan Pathol

DOI

ISSN

0303-6987

Publication Date

February 2006

Volume

33

Issue

2

Start / End Page

123 / 128

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Neprilysin
  • Neoplasms, Basal Cell
  • Middle Aged
  • Immunohistochemistry
  • Humans
  • Diagnosis, Differential
  • Dermatology & Venereal Diseases
  • Carcinoma, Basal Cell
  • Biomarkers, Tumor
 

Citation

APA
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ICMJE
MLA
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Pham, T. T. N., Selim, M. A., Burchette, J. L., Madden, J., Turner, J., & Herman, C. (2006). CD10 expression in trichoepithelioma and basal cell carcinoma. J Cutan Pathol, 33(2), 123–128. https://doi.org/10.1111/j.0303-6987.2006.00283.x
Pham, Teresa Tram N., M Angelica Selim, James L. Burchette, John Madden, John Turner, and Christopher Herman. “CD10 expression in trichoepithelioma and basal cell carcinoma.J Cutan Pathol 33, no. 2 (February 2006): 123–28. https://doi.org/10.1111/j.0303-6987.2006.00283.x.
Pham TTN, Selim MA, Burchette JL, Madden J, Turner J, Herman C. CD10 expression in trichoepithelioma and basal cell carcinoma. J Cutan Pathol. 2006 Feb;33(2):123–8.
Pham, Teresa Tram N., et al. “CD10 expression in trichoepithelioma and basal cell carcinoma.J Cutan Pathol, vol. 33, no. 2, Feb. 2006, pp. 123–28. Pubmed, doi:10.1111/j.0303-6987.2006.00283.x.
Pham TTN, Selim MA, Burchette JL, Madden J, Turner J, Herman C. CD10 expression in trichoepithelioma and basal cell carcinoma. J Cutan Pathol. 2006 Feb;33(2):123–128.
Journal cover image

Published In

J Cutan Pathol

DOI

ISSN

0303-6987

Publication Date

February 2006

Volume

33

Issue

2

Start / End Page

123 / 128

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Neprilysin
  • Neoplasms, Basal Cell
  • Middle Aged
  • Immunohistochemistry
  • Humans
  • Diagnosis, Differential
  • Dermatology & Venereal Diseases
  • Carcinoma, Basal Cell
  • Biomarkers, Tumor