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Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin.

Publication ,  Journal Article
Lin, F-H; Lin, J-Y; Gupta, RD; Tournas, JA; Burch, JA; Selim, MA; Monteiro-Riviere, NA; Grichnik, JM; Zielinski, J; Pinnell, SR
Published in: J Invest Dermatol
October 2005

Ferulic acid is a potent ubiquitous plant antioxidant. Its incorporation into a topical solution of 15%l-ascorbic acid and 1%alpha-tocopherol improved chemical stability of the vitamins (C+E) and doubled photoprotection to solar-simulated irradiation of skin from 4-fold to approximately 8-fold as measured by both erythema and sunburn cell formation. Inhibition of apoptosis was associated with reduced induction of caspase-3 and caspase-7. This antioxidant formulation efficiently reduced thymine dimer formation. This combination of pure natural low molecular weight antioxidants provides meaningful synergistic protection against oxidative stress in skin and should be useful for protection against photoaging and skin cancer.

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Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

October 2005

Volume

125

Issue

4

Start / End Page

826 / 832

Location

United States

Related Subject Headings

  • Vitamin E
  • Ultraviolet Rays
  • Swine
  • Skin Aging
  • Radiation-Protective Agents
  • Drug Stability
  • Dermatology & Venereal Diseases
  • Coumaric Acids
  • Ascorbic Acid
  • Animals
 

Citation

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Lin, F.-H., Lin, J.-Y., Gupta, R. D., Tournas, J. A., Burch, J. A., Selim, M. A., … Pinnell, S. R. (2005). Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. J Invest Dermatol, 125(4), 826–832. https://doi.org/10.1111/j.0022-202X.2005.23768.x
Lin, Fu-Hsiung, Jing-Yi Lin, Ravindra D. Gupta, Joshua A. Tournas, James A. Burch, M Angelica Selim, Nancy A. Monteiro-Riviere, James M. Grichnik, Jan Zielinski, and Sheldon R. Pinnell. “Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin.J Invest Dermatol 125, no. 4 (October 2005): 826–32. https://doi.org/10.1111/j.0022-202X.2005.23768.x.
Lin F-H, Lin J-Y, Gupta RD, Tournas JA, Burch JA, Selim MA, et al. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. J Invest Dermatol. 2005 Oct;125(4):826–32.
Lin, Fu-Hsiung, et al. “Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin.J Invest Dermatol, vol. 125, no. 4, Oct. 2005, pp. 826–32. Pubmed, doi:10.1111/j.0022-202X.2005.23768.x.
Lin F-H, Lin J-Y, Gupta RD, Tournas JA, Burch JA, Selim MA, Monteiro-Riviere NA, Grichnik JM, Zielinski J, Pinnell SR. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. J Invest Dermatol. 2005 Oct;125(4):826–832.
Journal cover image

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

October 2005

Volume

125

Issue

4

Start / End Page

826 / 832

Location

United States

Related Subject Headings

  • Vitamin E
  • Ultraviolet Rays
  • Swine
  • Skin Aging
  • Radiation-Protective Agents
  • Drug Stability
  • Dermatology & Venereal Diseases
  • Coumaric Acids
  • Ascorbic Acid
  • Animals