Basal cell-signet-ring squamous cell carcinoma of the eyelid.
A 93-year-old woman developed a mass on her right lower eyelid that was present for more than 6 months but underwent rapid expansion during several weeks prior to her ophthalmological evaluation. Examination revealed an approximately 1.8 cm in diameter, fleshy, fungating growth involving more than 60% of the right lower eyelid. Excisional biopsy disclosed a neoplasm arising from the epidermis composed of adjoining basal cell and signet-ring squamous cell carcinoma, without a transition zone. The cells comprising the basal and squamous cell carcinomas were distinct immunophenotypically, with only the basal cell carcinoma reacting with Ber-EP4 and CAM 5.2 antibodies. To our knowledge, this case represents the first example of a collision tumor composed of basal cell and signet-ring squamous cell carcinoma.
Duke Scholars
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Related Subject Headings
- Treatment Outcome
- Pathology
- Neoplasms, Multiple Primary
- Keratins
- Humans
- Female
- Eyelid Neoplasms
- Carcinoma, Squamous Cell
- Carcinoma, Signet Ring Cell
- Carcinoma, Basal Cell
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Treatment Outcome
- Pathology
- Neoplasms, Multiple Primary
- Keratins
- Humans
- Female
- Eyelid Neoplasms
- Carcinoma, Squamous Cell
- Carcinoma, Signet Ring Cell
- Carcinoma, Basal Cell