Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome.
Publication
, Journal Article
Blood-Siegfried, J; Nyska, A; Geisenhoffer, K; Lieder, H; Moomaw, C; Cobb, K; Shelton, B; Coombs, W; Germolec, D
Published in: FEMS immunology and medical microbiology
September 2004
Data increasingly implicate a possible role of immune and inflammatory responses to infection in sudden infant death syndrome (SIDS). We have previously described a dual challenge model that results in pathology, organ damage, vascular collapse and unexplained death similar to that seen in SIDS. In this study, we examined changes in inflammatory cytokine mRNA in the lung and liver and regulation of pathways associated with nitric oxide production. Our data suggest that priming of the immune system by mild viral infection disturbs normal inflammatory response to endotoxin. This results in an increased nitric oxide synthase production, most likely the cause of liver pathology and clotting abnormalities.
Duke Scholars
Published In
FEMS immunology and medical microbiology
DOI
EISSN
1574-695X
ISSN
0928-8244
Publication Date
September 2004
Volume
42
Issue
1
Start / End Page
85 / 93
Related Subject Headings
- Sudden Infant Death
- Rats, Inbred F344
- Rats
- RNA, Messenger
- Nitric Oxide Synthase Type II
- Nitric Oxide Synthase
- Microbiology
- Liver
- Influenza, Human
- Influenza A virus
Citation
APA
Chicago
ICMJE
MLA
NLM
Blood-Siegfried, J., Nyska, A., Geisenhoffer, K., Lieder, H., Moomaw, C., Cobb, K., … Germolec, D. (2004). Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome. FEMS Immunology and Medical Microbiology, 42(1), 85–93. https://doi.org/10.1016/j.femsim.2004.06.004
Blood-Siegfried, Jane, Abraham Nyska, Kristen Geisenhoffer, Holly Lieder, Cindy Moomaw, Kelly Cobb, Burton Shelton, William Coombs, and Dori Germolec. “Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome.” FEMS Immunology and Medical Microbiology 42, no. 1 (September 2004): 85–93. https://doi.org/10.1016/j.femsim.2004.06.004.
Blood-Siegfried J, Nyska A, Geisenhoffer K, Lieder H, Moomaw C, Cobb K, et al. Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome. FEMS immunology and medical microbiology. 2004 Sep;42(1):85–93.
Blood-Siegfried, Jane, et al. “Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome.” FEMS Immunology and Medical Microbiology, vol. 42, no. 1, Sept. 2004, pp. 85–93. Epmc, doi:10.1016/j.femsim.2004.06.004.
Blood-Siegfried J, Nyska A, Geisenhoffer K, Lieder H, Moomaw C, Cobb K, Shelton B, Coombs W, Germolec D. Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome. FEMS immunology and medical microbiology. 2004 Sep;42(1):85–93.
Published In
FEMS immunology and medical microbiology
DOI
EISSN
1574-695X
ISSN
0928-8244
Publication Date
September 2004
Volume
42
Issue
1
Start / End Page
85 / 93
Related Subject Headings
- Sudden Infant Death
- Rats, Inbred F344
- Rats
- RNA, Messenger
- Nitric Oxide Synthase Type II
- Nitric Oxide Synthase
- Microbiology
- Liver
- Influenza, Human
- Influenza A virus