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Animal models for medical countermeasures to radiation exposure.

Publication ,  Journal Article
Williams, JP; Brown, SL; Georges, GE; Hauer-Jensen, M; Hill, RP; Huser, AK; Kirsch, DG; Macvittie, TJ; Mason, KA; Medhora, MM; Moulder, JE ...
Published in: Radiat Res
April 2010

Since September 11, 2001, there has been the recognition of a plausible threat from acts of terrorism, including radiological or nuclear attacks. A network of Centers for Medical Countermeasures against Radiation (CMCRs) has been established across the U.S.; one of the missions of this network is to identify and develop mitigating agents that can be used to treat the civilian population after a radiological event. The development of such agents requires comparison of data from many sources and accumulation of information consistent with the "Animal Rule" from the Food and Drug Administration (FDA). Given the necessity for a consensus on appropriate animal model use across the network to allow for comparative studies to be performed across institutions, and to identify pivotal studies and facilitate FDA approval, in early 2008, investigators from each of the CMCRs organized and met for an Animal Models Workshop. Working groups deliberated and discussed the wide range of animal models available for assessing agent efficacy in a number of relevant tissues and organs, including the immune and hematopoietic systems, gastrointestinal tract, lung, kidney and skin. Discussions covered the most appropriate species and strains available as well as other factors that may affect differential findings between groups and institutions. This report provides the workshop findings.

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Published In

Radiat Res

DOI

EISSN

1938-5404

Publication Date

April 2010

Volume

173

Issue

4

Start / End Page

557 / 578

Location

United States

Related Subject Headings

  • United States
  • Radiation Protection
  • Radiation Injuries
  • Oncology & Carcinogenesis
  • Humans
  • Environmental Exposure
  • Disease Models, Animal
  • Animals
  • 4202 Epidemiology
  • 3407 Theoretical and computational chemistry
 

Citation

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Williams, J. P., Brown, S. L., Georges, G. E., Hauer-Jensen, M., Hill, R. P., Huser, A. K., … McBride, W. H. (2010). Animal models for medical countermeasures to radiation exposure. Radiation Research, 173(4), 557–578. https://doi.org/10.1667/rr1880.1
Williams, Jacqueline P., Stephen L. Brown, George E. Georges, Martin Hauer-Jensen, Richard P. Hill, Amy K. Huser, David G. Kirsch, et al. “Animal models for medical countermeasures to radiation exposure.Radiation Research 173, no. 4 (April 2010): 557–78. https://doi.org/10.1667/rr1880.1.
Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, et al. Animal models for medical countermeasures to radiation exposure. Radiation research. 2010 Apr;173(4):557–78.
Williams, Jacqueline P., et al. “Animal models for medical countermeasures to radiation exposure.Radiation Research, vol. 173, no. 4, Apr. 2010, pp. 557–78. Epmc, doi:10.1667/rr1880.1.
Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, Macvittie TJ, Mason KA, Medhora MM, Moulder JE, Okunieff P, Otterson MF, Robbins ME, Smathers JB, McBride WH. Animal models for medical countermeasures to radiation exposure. Radiation research. 2010 Apr;173(4):557–578.

Published In

Radiat Res

DOI

EISSN

1938-5404

Publication Date

April 2010

Volume

173

Issue

4

Start / End Page

557 / 578

Location

United States

Related Subject Headings

  • United States
  • Radiation Protection
  • Radiation Injuries
  • Oncology & Carcinogenesis
  • Humans
  • Environmental Exposure
  • Disease Models, Animal
  • Animals
  • 4202 Epidemiology
  • 3407 Theoretical and computational chemistry