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Multishot PROPELLER for high-field preclinical MRI.
With the development of numerous mouse models of cancer, there is a tremendous need for an appropriate imaging technique to study the disease evolution. High-field T(2)-weighted imaging using PROPELLER (Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction) MRI meets this need. The two-shot PROPELLER technique presented here provides (a) high spatial resolution, (b) high contrast resolution, and (c) rapid and noninvasive imaging, which enables high-throughput, longitudinal studies in free-breathing mice. Unique data collection and reconstruction makes this method robust against motion artifacts. The two-shot modification introduced here retains more high-frequency information and provides higher signal-to-noise ratio than conventional single-shot PROPELLER, making this sequence feasible at high fields, where signal loss is rapid. Results are shown in a liver metastases model to demonstrate the utility of this technique in one of the more challenging regions of the mouse, which is the abdomen.
Duke Scholars
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Related Subject Headings
- Radiography, Abdominal
- Nuclear Medicine & Medical Imaging
- Mice, Inbred C57BL
- Mice
- Magnetic Resonance Imaging
- Liver Neoplasms, Experimental
- Image Processing, Computer-Assisted
- Female
- Disease Models, Animal
- Animals
Citation
![Journal cover image](https://secure.syndetics.com/index.aspx?isbn=/lc.gif&issn=1522-2594&client=dukeuniv)
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Radiography, Abdominal
- Nuclear Medicine & Medical Imaging
- Mice, Inbred C57BL
- Mice
- Magnetic Resonance Imaging
- Liver Neoplasms, Experimental
- Image Processing, Computer-Assisted
- Female
- Disease Models, Animal
- Animals