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Intensity of lactation modulates renal 1 alpha-hydroxylase and serum 1,25(OH)2D in rats.

Publication ,  Journal Article
Lobaugh, B; Boass, A; Garner, SC; Toverud, SU
Published in: Am J Physiol
June 1992

Renal 25-hydroxyvitamin D-1 alpha-hydroxylase (1 alpha-hydroxylase) activity and serum 1,25-dihydroxyvitamin D [1,25(OH)2D] concentration were measured in lactating rats suckling litters of 3, 6, or 12 pups to determine the effect of increasing lactational intensity on the biosynthesis of 1,25(OH)2D. Serum Ca2+, total Ca, Pi, and immunoreactive parathyroid hormone were also determined. The average daily litter weight gain for each litter size was calculated from the gain over the last 4-6 days of each of three experiments and was used as an index of lactational intensity. Highly significant correlation coefficients were found between 1 alpha-hydroxylase and average daily litter weight gain (rs = 0.63, n = 53, P less than 0.001), serum 1,25(OH)2D and average daily litter weight gain (rs = 0.62, n = 50, P less than 0.001), 1 alpha-hydroxylase and serum total Ca (rs = -0.52, n = 53, P less than 0.001), and average daily litter weight gain and total Ca (rs = -0.52, n = 53, P less than 0.001). Neither serum phosphorus nor immunoreactive parathyroid hormone correlated significantly with 1 alpha-hydroxylase. In addition, construction of regression models using a stepwise forward variable selection procedure revealed serum total Ca concentration to be a significant predictor for both serum 1,25(OH)2D and renal 1 alpha-hydroxylase in lactating rats. These data support the hypothesis that increasing lactational intensity leads to decreasing serum Ca concentration, resulting in stimulation of 1 alpha-hydroxylase activity and a rise in the serum 1,25(OH)2D level.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

June 1992

Volume

262

Issue

6 Pt 1

Start / End Page

E840 / E844

Location

United States

Related Subject Headings

  • Regression Analysis
  • Rats
  • Pregnancy
  • Litter Size
  • Lactation
  • Kidney
  • Female
  • Cardiovascular System & Hematology
  • Calcitriol
  • Body Weight
 

Citation

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Lobaugh, B., Boass, A., Garner, S. C., & Toverud, S. U. (1992). Intensity of lactation modulates renal 1 alpha-hydroxylase and serum 1,25(OH)2D in rats. Am J Physiol, 262(6 Pt 1), E840–E844. https://doi.org/10.1152/ajpendo.1992.262.6.E840
Lobaugh, B., A. Boass, S. C. Garner, and S. U. Toverud. “Intensity of lactation modulates renal 1 alpha-hydroxylase and serum 1,25(OH)2D in rats.Am J Physiol 262, no. 6 Pt 1 (June 1992): E840–44. https://doi.org/10.1152/ajpendo.1992.262.6.E840.
Lobaugh B, Boass A, Garner SC, Toverud SU. Intensity of lactation modulates renal 1 alpha-hydroxylase and serum 1,25(OH)2D in rats. Am J Physiol. 1992 Jun;262(6 Pt 1):E840–4.
Lobaugh, B., et al. “Intensity of lactation modulates renal 1 alpha-hydroxylase and serum 1,25(OH)2D in rats.Am J Physiol, vol. 262, no. 6 Pt 1, June 1992, pp. E840–44. Pubmed, doi:10.1152/ajpendo.1992.262.6.E840.
Lobaugh B, Boass A, Garner SC, Toverud SU. Intensity of lactation modulates renal 1 alpha-hydroxylase and serum 1,25(OH)2D in rats. Am J Physiol. 1992 Jun;262(6 Pt 1):E840–E844.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

June 1992

Volume

262

Issue

6 Pt 1

Start / End Page

E840 / E844

Location

United States

Related Subject Headings

  • Regression Analysis
  • Rats
  • Pregnancy
  • Litter Size
  • Lactation
  • Kidney
  • Female
  • Cardiovascular System & Hematology
  • Calcitriol
  • Body Weight