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Equivalency of various methods for estimating osteoid seam width.

Publication ,  Journal Article
Quarles, LD; Lobaugh, B
Published in: J Bone Miner Res
October 1989

We compared the true osteoid seam width (TOSW) as measured by a modification of the orthogonal intercept lengths with various methods of estimating seam widths, including (1) the commonly used length measurements at four equidistant points (O.Wi/4PT), (2) osteoid area divided by the osteoid perimeter (O.Ar/O/Pm) or the bone/osteoid interface (O.Ar/B.Bd), and (3) a novel method for estimating seam width defined as the osteoid area divided by the major axis of the seam (O.Ar/Axis). All methods for approximating osteoid seam width significantly exaggerated the true osteoid seam dimension by an amount that ranged from 16 to 23%. However, the relative accuracy of all methods of estimating osteoid seam width are equivalent as evidenced by the similar mean difference from the TOSW (3.4, 4.1, 5.1, and 3.8) demonstrated by O.Wi/5PT, O.Ar/Axis, O.Ar/O.Pm, O.Ar/B.Bd, respectively. Regression analysis of the various estimates of seam width on TOSW also demonstrated the equivalency of these methods. Moreover, all estimates could be employed to discriminate seams of normal dimensions from abnormally wide seams in bone specimens derived from patients with osteomalacia. Differences between the methods, however, were observed that may have practical importance. In this regard, the direct procedure of determining distance demonstrated less variance than the indirect estimate of width. As a result, the direct measurement required fewer samples (n = 13) to detect a significant difference to normal and could discriminate smaller deviations in seam width (1.7 microns) at a given sample size compared with O.Ar/Axis (n = 28; 2.9 microns), O.Ar/O.Pm (n = 42; 3.4 microns), and O.Ar/B.Bd (n = 42; n = 3.2).(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

J Bone Miner Res

DOI

ISSN

0884-0431

Publication Date

October 1989

Volume

4

Issue

5

Start / End Page

671 / 677

Location

England

Related Subject Headings

  • Regression Analysis
  • Osteomalacia
  • Methods
  • Humans
  • Bone Matrix
  • Anatomy & Morphology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 09 Engineering
 

Citation

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Quarles, L. D., & Lobaugh, B. (1989). Equivalency of various methods for estimating osteoid seam width. J Bone Miner Res, 4(5), 671–677. https://doi.org/10.1002/jbmr.5650040505
Quarles, L. D., and B. Lobaugh. “Equivalency of various methods for estimating osteoid seam width.J Bone Miner Res 4, no. 5 (October 1989): 671–77. https://doi.org/10.1002/jbmr.5650040505.
Quarles LD, Lobaugh B. Equivalency of various methods for estimating osteoid seam width. J Bone Miner Res. 1989 Oct;4(5):671–7.
Quarles, L. D., and B. Lobaugh. “Equivalency of various methods for estimating osteoid seam width.J Bone Miner Res, vol. 4, no. 5, Oct. 1989, pp. 671–77. Pubmed, doi:10.1002/jbmr.5650040505.
Quarles LD, Lobaugh B. Equivalency of various methods for estimating osteoid seam width. J Bone Miner Res. 1989 Oct;4(5):671–677.
Journal cover image

Published In

J Bone Miner Res

DOI

ISSN

0884-0431

Publication Date

October 1989

Volume

4

Issue

5

Start / End Page

671 / 677

Location

England

Related Subject Headings

  • Regression Analysis
  • Osteomalacia
  • Methods
  • Humans
  • Bone Matrix
  • Anatomy & Morphology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 09 Engineering